Intradermal yellow fever vaccination with a reduced dose will induce a sufficient protective immunological response comparable to the response elicited by subcutaneous yellow fever vaccination.
ID
Bron
Verkorte titel
Aandoening
(Prevention of) yellow fever.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Protective humoral immune response. <br>
For first time vaccinees measured 4 and 8 weeks post-vaccination, for revaccinees measured 2 weeks post-vaccination. <br>
All sera will be analysed by ELISA, Immunofluorescence and plaque reduction assay.
Achtergrond van het onderzoek
Comparison between effectivity of different methods of vaccination; antibody response to intradermal and subcutaneous yellow fever vaccination, measured by ELISA, IF and plaque reduction assay.
Furthermore adverse events will be studied by keeping a diary, and viremia will be measured in a subgroup of the first time vaccinees and the revaccinees.
Doel van het onderzoek
Intradermal yellow fever vaccination with a reduced dose will induce a sufficient protective immunological response comparable to the response elicited by subcutaneous yellow fever vaccination.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Subcutaneous of intradermal yellow fever vaccination.
Publiek
P.O. Box 9600
A.H.E. Roukens
Albinusdreef 2
Leiden 2300 RC
The Netherlands
a.h.e.roukens@lumc.nl
Wetenschappelijk
P.O. Box 9600
A.H.E. Roukens
Albinusdreef 2
Leiden 2300 RC
The Netherlands
a.h.e.roukens@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy volunteers, >18yrs (previously and not previously vaccinated with yellow fever vaccine).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Pregnancy;
2. Diabetes mellitus;
3. Use of immunomodulating medication e.g. corticosteroids;
4. Cytostatica;
5. Use of chloroquine.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL194 |
| NTR-old | NTR231 |
| Ander register | : N/A |
| ISRCTN | ISRCTN46326316 |