We hypothesize that, compared with standard management, NoL-guided anesthesia will lead to reduced incidence of inadequate anesthesia and increased hemodynamic stability. Furthermore, we hypothesize that NoL-guided anesthesia leads to reduced…
ID
Bron
Verkorte titel
Aandoening
- Analgesia
- Anesthesia
- Nociceptive level index
- Intraoperative monitoring
- Haemodynamics
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Opioid and propofol consumption in total dose and dose/min; and <br>
2. Incidence (number of episodes) and total duration of inadequate anesthesia
Doel van het onderzoek
We hypothesize that, compared with standard management, NoL-guided anesthesia will lead to reduced incidence of inadequate anesthesia and increased hemodynamic stability. Furthermore, we hypothesize that NoL-guided anesthesia leads to reduced recovery times, reduced postoperative pain scores and PONV and faster PACU discharge (readiness) times.
Onderzoeksopzet
Perioperative period: intraoperative analgesia consumption and haemodynamics; postoperative pain, medication use, nausea/vomiting
Onderzoeksproduct en/of interventie
Nociceptive level guided analgesia
Publiek
Department of Anesthesiology,
P.O. Box 9600
Albert Dahan
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
a.dahan@lumc.nl
Wetenschappelijk
Department of Anesthesiology,
P.O. Box 9600
Albert Dahan
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
a.dahan@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age: 18-80 years;
2. ASA I-II-III
3. Elective open abdominal surgery or laparoscopic assisted abdominal surgery.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Unable to give written informed consent;
2. Use of epidural analgesia or local anesthesia (eg. transversus abdominal plain block, TAP block)
3. Non-elective surgery
4. Pregnancy/lactation;
5. BMI > 35 kg/m2;
6. Uncontrolled preoperative hypo- or hypertension (Mean arterial pressure < 60 mmHg or > 100 mmHg)
7. Preoperative Heart rate < 45/min or > 90/min;
8. Central nervous system disorder (neurologic/head trauma/uncontrolled epileptic seizures);
9. Illicit substance or alcohol abuse within 30 days;
10. Chronic use of pain medication within 30 days;
11. Chronic use of psychoactive drugs within 30 days;
12. Significant medical condition
a. Untreated or persistent peripheral or central cardiovascular disease
b. Severe pulmonary disease e.g. COPD gold 4 , FEV< 1.0 L/s, or (evidence of) elevated paCO2 > 6.0 kPa
c. Significant hepatic disease with increased bilirubin, INR or low albumin
13. Beta blocker use
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6002 |
| NTR-old | NTR6500 |
| Ander register | NL56370.058.15 : p16019 |