We expect to demonstrate that ctDNA can be reliably detected in patients with perihilar cholangiocarcinoma.
ID
Bron
Verkorte titel
Aandoening
Perihilar cholangiocarcinoma/ Perihilair cholangiocarcinoom
Klatskin-tumor
Biomarker
Circulating tumor DNA /Circulerend tumor DNA (ctDNA)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The aim of this study is to investigate if ctDNA is detectable in the blood of patients with pathologically proven PHC.
Achtergrond van het onderzoek
In suspected perihilar cholangiocarcinoma, the current diagnostic options are inadequate. Furthermore, a reliable biomarker that can be used for followup desirable. Circulating tumor DNA is promising in this regard.
The aim of this project is the detection and analysis of ctDNA in perihilar cholangiocarcinoma patients. A condition for the applicability of ctDNA as a biomarker is that the mutation profiles found in ctDNA and the tumor tissue are identical. For this reason, both tumor tissue and ctDNA will be sequenced.
Doel van het onderzoek
We expect to demonstrate that ctDNA can be reliably detected in patients with perihilar cholangiocarcinoma.
Onderzoeksopzet
We hope to have collected the 20 patient samples before May 2017.
Onderzoeksproduct en/of interventie
None
Publiek
Eline Soer
PO Box 22660
Amsterdam 1100 DD
The Netherlands
e.c.soer@amc.uva.nl
Wetenschappelijk
Eline Soer
PO Box 22660
Amsterdam 1100 DD
The Netherlands
e.c.soer@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
-Patients older than 18 years.
-Undergoing explorative laparotomy, diagnostic laparoscopy or percutaneous biopsy.
-Able to understand the information given and provide written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
-Patients 18 years or younger.
-Unfit for laparotomy/ diagnostic laparoscopy/ biopsies or blood analyses in palliative
chemotherapy studies.
-HIV/AIDS/hepatitis C in medical history.
-Not able to give informed consent (language, intellectual capacities, etc.).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5793 |
| NTR-old | NTR6068 |
| Ander register | : Protocol ID: NL58159.018.16 |