Effects of brain stimulation on metabolism.

Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production. By turning the stimulator on and off, insight will be given in the effect on the metabolism.

Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production.

Start 1-1-2009.

2 study days which take 8 hours each. Blood withdrawal every hour during 8 hours and within those hours we also perform a hyperinsulinemic euglycemic clamp.