Advanced glycation endproducts (AGEs) may play a role in the development of PVR and hence surgical failure. Possibly, autofluorescence of AGEs in the skin, measured by the simple non-invasive AGE reader, could be used as a predictor for post-…
ID
Bron
Verkorte titel
Aandoening
Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition, most often initiated by a posterior vitreous detachment-associated retinal tear. A recent study found an incidence of RRD in the Netherlands of 18.2 per 100,000 people.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Surgical failure
Achtergrond van het onderzoek
The aim of this study is to investigate whether skin autofluorescence (AF) is predictive of postoperative PVR (and corresponding surgical failure) in patients being surgically treated for retinal detachment and to investigate some pathways which may contribute to the explanation of the relation of systemic skin AF with local eye disease.
The objectives will be tested in a prospective cohort study in patients who will undergo vitrectomy because of retinal detachment
Doel van het onderzoek
Advanced glycation endproducts (AGEs) may play a role in the development of PVR and hence surgical failure. Possibly, autofluorescence of AGEs in the skin, measured by the simple non-invasive AGE reader, could be used as a predictor for post-operative proliferative vitreoretinopathy and surgical failure in patients with retinal detachment.
Onderzoeksopzet
1. Surgical failure - Re-detachment - Timepoint: 3 months
2. Skin autofluorescence - AGE reader MU - Timepoint: 0
Vitreous biopsy - timepoint: 0 - 14 days
3. Vitreous body AGE levels - high performance liquid chromatography (HPLC)- Timepoint: After inclusion of all patients.
4. Vitreous body sRAGE levels - Enzyme linked immunosorbent (ELISA) techniques - Timepoint: After inclusion of all patients.
5. plasma sRAGE levels - Enzyme linked immunosorbent (ELISA) techniques - Timepoint: After inclusion of all patients.
6. Glyoxalase polymorphisms - Genotyping techniques - Timepoint: After inclusion of all patients.
7. RAGE polymorphisms - Genotyping techniques - Timepoint: After inclusion of all patients.
8. Age - Timepoint:0
9. gender - Timepoint:0
10. surface area of retinal detachment - Timepoint: Vitreous biopsy
11. number of retinal defects - Timepoint: Vitreous biopsy
12. macular detachment - Timepoint: Vitreous biopsy
13. detachment duration - Timepoint: Vitreous biopsy
14. pre-operative PVR grade - Timepoint: Vitreous biopsy
15. presence of diabetes - Timepoint:0
16. pseudophakia - Timepoint: 0
17. intraoperative use of gas or silicon oil - Timepoint: Vitreous biopsy
18. intraoperative cryotherapy, intraoperative minor hemorrhage - Timepoint: Vitreous biopsy
Onderzoeksproduct en/of interventie
None
Publiek
Department of Ophthalmology
P.O. Box 30.001
L.I. Los
Groningen 9700 RB
The Netherlands
+31 (0)50 3612510
l.i.los@ohk.umcg.nl
Wetenschappelijk
Department of Ophthalmology
P.O. Box 30.001
L.I. Los
Groningen 9700 RB
The Netherlands
+31 (0)50 3612510
l.i.los@ohk.umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Willingness to participate.
2. Patients, newly diagnosed with retinal detachment, scheduled for vitrectomy.
3. Age: >18 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Dark coloured skin that impairs the reliability of the autofluorescence measurement.
2. Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement.
3. Local or general active infection or inflammatory disease.
4. Known renal disease with impairment of renal function class CKD ≥3 (≤ 60 ml/min according to eGFR), current dialysis treatment, or a history of renal transplantation.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4145 |
| NTR-old | NTR4289 |
| Ander register | METc UMCG : METc 2013/153 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |