De rol van hypocretine in het aansturen van eetgedrag

- Age: 18-60 years old

- Right-handed

- BMI-range between 20-35.

Control group:

- No current sleep, neurological or psychiatric disorder

- Will be matched on age and BMI (range 20-35) with patient groups

Patient groups:

- Narcolepsy with cataplexy, or primary hypersomnia (either narcolepsy without cataplexy or idiopathic hypersomnia without long sleep time). All disorders should have been diagnosed according to the International Classification of Sleep Disorders – Second Edition (ICSD-2) criteria (American_Academy_of_Sleep_Medicine, 2005).

- All patients who take medication should be willing and able to withdraw from taking medication for 1 week.

- Diabetes Mellitus

- (History of) clinically significant hepatic, cardiac, renal, cerebro-vascular, endocrine, metabolic or pulmonary disease

- Uncontrolled hypertension, defined as diastolic blood pressure at rest > 90 mmHg or systolic blood pressure at rest > 160 mmHg

- (History of) clinically significant neurological or psychiatric disorders and current psychological treatment other than narcolepsy or idiopathic hypersomnia.

- Deafness, blindness, or sensory-motor handicaps

- History of taste or smell impairments

- Drug, alcohol or gamble addiction in the past 6 months

- Inadequate command of Dutch language

- Extreme restraint eating (i.e. score restraint eating ≥3.60 (females) or ≥ 4.00 (males) on the Dutch Eating Behaviour Questionnaire; see also section 6.3.4)

- Current, strict dieting (i.e. specific diet and/or in treatment with dietician)

- Food allergy to one of the ingredients used in the food rewards

- Contra-indications for MRI:

o Metal objects or fragments in the body that cannot be taken out

o Active implants in the body

o Using medical plasters

o Epilepsy

o Previous head surgery

o Pregnancy

o Claustrophobia