Children with intestinal failure who receive a profound percentage of total kilocalories by parenteral nutrition for aprolonged period have altered body composition, poorer growth and bone health compared to children with intestinal failure off…
ID
Bron
Verkorte titel
Aandoening
Intestinal failure; body composition; growth; bone health.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Body composition measured, defined by %BF
Parenteral nutrition (time-weighted area under the curve for % of total kilocalories provided by parenteral nutrition and duration of PN)
Achtergrond van het onderzoek
In this prospective, observational study we investigate the relationship between body composition, growth and parenteral nutrition in children with intestinal failure. In addition, we investigate the bone health of children with intestinal failure.
Doel van het onderzoek
Children with intestinal failure who receive a profound percentage of total kilocalories by parenteral nutrition for aprolonged period have altered body composition, poorer growth and bone health compared to children with intestinal failure off parenteral nutrition or children with less parenteral nutrition.
Onderzoeksopzet
The duration of the study for each subject will last two years. There will be 12 visits during this study, but only when the patient is admitted or visiting the outpatient clinic. For children already known with intestinal failure, there will be 8 visits.
Onderzoeksproduct en/of interventie
N/A
Publiek
JM Hulst
Wytemaweg 80
Rotterdam 3015 CN
The Netherlands
0107036049
j.hulst@erasmusmc.nl
Wetenschappelijk
JM Hulst
Wytemaweg 80
Rotterdam 3015 CN
The Netherlands
0107036049
j.hulst@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Children, newly diagnosed with intestinal failure in the Erasmus MC-Sophia Children's Hospital. Three groups of children will be included:
1. Children with congenital gastro-intestinal anomalies with involvement of the small intestine, independent of expected use of parenteral nutrition.
2. Neonates with an expected use of parenteral nutrition ≥ 1 week after a gastrointestinal intervention (laparotomy).
3. Children with a (suspected) motility disorder or intrinsic disorder of the intestinal mucosa with an expected use of parenteral nutrition > 2 weeks and children with an expected use of parenteral nutrition ≥ 1 week after a gastrointestinal intervention (laparotomy) after the neonatal period.
Furthermore, children already known with intestinal failure who receive parenteral nutrition at home and visit the intestinal failure outpatient clinic will be included, both in the Erasmus MC - Sophia Children's Hospital and the AMC - Emma Children's Hospital.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Participating in an intervention study, interfering with primary outcome of this study.
Absence of written informed consent
Insufficient knowledge of the Dutch language
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5892 |
| NTR-old | NTR6080 |
| Ander register | MEC : 2015-002 |