The small spectrum antibiotic flucloxacillin is approved in an intermittent dosing regime. The antibacterial activity of flucloxacillin is time dependent so continuous infusion is probably more effective. Furthermore, for some patients continuous…
ID
Bron
Verkorte titel
Aandoening
infections
kinetics
infusion
flucloxacillin
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Part A: (step 1) A quantitative description of the pharmacokinetics flucloxacillin in non-critically ill patients: changes in (unbound) flucloxacillin level-time profiles and the possible relationship with renal function and demographics. Step 2: A dosing regime for continuous administration of flucloxacillin in which 90% of the population exceeds 100% fT>MIC. Part B: The percentage of patients exceeding the PK target of 100% fT>MIC with the new dosing regime.
Achtergrond van het onderzoek
waiting for MEC approval
Doel van het onderzoek
The small spectrum antibiotic flucloxacillin is approved in an intermittent dosing regime. The antibacterial activity of flucloxacillin is time dependent so continuous infusion is probably more effective. Furthermore, for some patients continuous dosing can have practical benefits. As it stands, the optimal flucloxacillin dosage for continuous infusion is unknown. Studies indicate that a lower dosage of continuous infusion might be sufficient.
Onderzoeksopzet
after finishing flucloxacillin therapy
Onderzoeksproduct en/of interventie
Part A: none
Part B: altered dosage flucloxacillin
Publiek
Sarah Wilkes
Deventer 7416 SE
The Netherlands
T: (0570) 53 6242
E: s.wilkes@dz.nl
Wetenschappelijk
Sarah Wilkes
Deventer 7416 SE
The Netherlands
T: (0570) 53 6242
E: s.wilkes@dz.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- The patient is at least 18 years of age
- The patient has started with intravenous flucloxacillin as indicated by their physician
Part B
The patient is at least 18 years of age
- The patient has an indication for the treatment of flucloxacillin with continuous infusion as indicated by their physician
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
The patient who is admitted to the intensive care unit
- Pregnant women
Opzet
Deelname
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