Gastrointestinal tolerance of an upgraded peptide feed in ICU patients

Main inclusion criteria:

• Age >=18 years;

• Admitted to the ICU;

• Expected to be on tube feeding for >=5 days;

• Start of tube feeding within 48 hours after ICU admission

Main exclusion criteria:

• Requiring other tube feed for medical reason;

• Not suitable for tube feeding;

• Allergy or intolerance for cow’s milk protein, soy or pea protein;

• Gastrointestinal disease such as Crohn’s or Ulcerative Colitis or other conditions affecting absorption such as short bowel syndrome;

• Pancreatic, liver or renal failure;

• Sequential organ failure assessment (SOFA) score >12 within first 24 hours after admission;

• Being pregnant;

• Participating in another clinical intervention trial