Unfavorable exposures during the early postnatal period change programming of growth and metabolic pathways, thereby deranging infant’s body composition and increasing the risk for later obesity and diabetes type 2
ID
Bron
Verkorte titel
Aandoening
Obesity, diabetes type II, cardiovascular diseases
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Prenatal and postnatal growth trajectories and prenatal maternal exposures in association with body composition at ages 1, 3, 6 and 9 months with the modification of infants nutritional intake
Achtergrond van het onderzoek
Evidence is rising that low birth weight for gestational age and rapid postnatal catch-up growth are risk factors for the development of obesity and diabetes type 2 in adulthood. It has been demonstrated that the early postnatal period is a critical window for the programming of various pathways in tissues and organs, in which nutrition is an important determinant. Up until now pilot data show that rapid postnatal weight gain during the first 3 months of life might cause accelerated fat accumulation which in turn will track into adulthood, but until now it remained difficult to assess infant body composition properly.
Doel van het onderzoek
Unfavorable exposures during the early postnatal period change programming of growth and metabolic pathways, thereby deranging infant’s body composition and increasing the risk for later obesity and diabetes type 2
Onderzoeksopzet
1, 3, 6, 9, 12, 18 and 24 months
Publiek
Kirsten de Fluiter
+31-10-7037174
k.defluiter@erasmusmc.nl
Wetenschappelijk
Kirsten de Fluiter
+31-10-7037174
k.defluiter@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Inclusion criteria parents:
- Capability of the parents to comply with study protocol.
- Knowledge of the Dutch language.
Inclusion criteria newborns:
- Healthy and full-term infants (gestational age ≥ 36 weeks).
- Children with a neonatal period without severe asphyxia (defined as a Apgar score <3 after 5 minutes), and no serious disease such as long-term artificial ventilation and oxygen supply, broncho pulmonary dysplasia or other lung disease
- Written informed consent from both parents.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Exclusion criteria parents:
- Maternal use of corticosteroids during pregnancy.
- Pregnant women/parents known to have other significant medical condition (including during pregnancy) that might interfere with the study or known to affect intra-uterine growth as per investigator’s clinical judgment.
Exclusion criteria newborns:
- Confirmed intra-uterine infection.
- Infants with chromosomal disorders, known syndromes and serious dismorphic symptoms suggestive for a (yet unknown) syndrome.
- Any endocrine or metabolic disorder such as diabetes mellitus, diabetes insipidus, hypothyroidism, or inborn errors of metabolism.
- Infants known to have current or previous illnesses/conditions or intervention which could interfere with the study, such as certain medication (e.g. cortical steroids) or major surgery, as per investigator’s clinical judgement.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7833 |
| Ander register | METC Erasmus Medical Center : MEC-2012-164 |