TAMI Trial

Rationale: Little is known about the risk for manifestations of cardiac ischemia due to Drugs Of Abuse (DOA). The strong correlation between cocaine and Acute Myocardial Infarction (AMI) at a young age is well studied. However, the relation between cardiac ischemia and other DOA remains unclear.
Objective: The aim of this study is to evaluate the incidence of DOA use in young adults aged 18-45 years old, diagnosed with an Acute Myocardial Infarction.
Study design: Multicenter exploratory cohort study
Study population: Adults aged18 till 45 years old diagnosed with AMI (all subtypes) in the Emergency Department (ED) or Coronary Care Unit (CCU) of the OLVG hospital and the Amsterdam UMC in Amsterdam, the Netherlands.
Intervention: No interventions are performed
Main study parameters/endpoints: The main endpoint is the number of patients and type of DOA that patients with AMI test positive for using the Toxtyper test.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: There is no risk or burden for participants as no extra interventions are performed. An extra blood sample is collected for Toxtyper testing during routine blood tests that are taken within common practice for treating AMI.

25% of AMI in patients >17 and <45 years old have a positive toxtyper screening for recreational drug use

Start 1 march 2020

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