Acute whole-body heat treatment beneficially affects hepatic insulin sensitivity
ID
Bron
Verkorte titel
Aandoening
glucose metabolism
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
hepatic insulin sensitivity
Achtergrond van het onderzoek
Rationale: In a recent study, for the first time it has been shown that repeated exposure to heat beneficially affects liver metabolism and induces a change in whole-body substrate use. After 10 days of mild heat acclimation (6h per day, 10 consecutive days), rate of [glucose] disappearance (Rd) and endogenous glucose production (EGP) were reduced in a fasted state, indicating improved glucose homeostasis. Additionally, fat oxidation was increased after acclimation. Importantly, although it has been shown that parameters of liver metabolism improve after repeated whole-body heat exposure, it is unknown what the acute effects of whole-body heat exposure are on the hepatic insulin sensitivity. In order to get a superior understanding of the underlying mechanisms and relationships between heat and metabolism, and how acclimation effects build up and are established, the present study aims to assess the effect of acute whole-body heat exposure on insulin sensitivity, substrate use and related blood parameters in healthy obese volunteers.
Primary objective: Assess the effect of acute, passively administered whole-body heat exposure on
• hepatic insulin sensitivity
• whole-body substrate oxidation
• plasma metabolites.
Secondary objective: Assess the effect of acute, passively administered whole-body heat exposure on
• measures of thermophysiology,
• cardiovascular parameters
• thermal perception (thermal sensation and comfort)
Study design: Randomised cross-over design. Two one-step hyperinsulinemic-euglycemic clamps with a low dose of insulin (10mU/m2/min) will be performed to determine liver-specific insulin sensitivity in a) a thermoneutral condition and b) during passive whole-body heat exposure (Figure 1).
Study population: Healthy obese volunteers between 40-70 years, BMI 25-35kg/m2
Intervention (if applicable): Passive heat exposure (core temperature elevated over the course of the hyperinsulinemic-euglycemic clamp to approximately 37.5˚C)
Doel van het onderzoek
Acute whole-body heat treatment beneficially affects hepatic insulin sensitivity
Onderzoeksopzet
2
Onderzoeksproduct en/of interventie
Whole-body heat treatment
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
• Signed informed consent
• Men and women
• Caucasian / white western European
• Aged 40-70 years at the start of the study
• Body mass index (BMI) 25-35 kg/m2
• Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
• months
• Stable sedentary lifestyle (not more than 2 hours of sports per week)
• Women after their menopause, meaning no menstrual cycle for at least 24 months and only if they are not under hormonal treatment.
• Generally healthy, no medication use that interferes with metabolism. If volunteers need medication, it will be reviewed with the dependent physician on individual basis.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
• Haemoglobin <8.4mmol/L
• Use of cholesterol or lipid-lowering medication
• Active pregnancy
• No signs of active uncontrolled hypertension, liver or kidney malfunction
• Cardiac problems and cardiovascular diseases, such as angina pectoris, cardiac infarction and arrhythmias
• Any medical condition requiring treatment and/or medication that might interfere with the investigated parameters. All medical conditions/medications will be reviewed with the dependent physician and in-/exclusion will be decided on individual basis
• Anticoagulation medication
• Unstable body weight (weight gain or loss >3kg in the past three months)
• Participation in another biomedical study within 1 month prior to screening visit
• Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
• Blood donation three months prior to study and three months after finishing the study
• Alcohol consumption of >2 servings per day Smoking in the past 6 months
• Women if they don’t take oral contraceptives for at least 3 menstrual cycle
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7829 |
| CCMO | NL7829 (METC will follow later) |