Multivariate Nuclear Magnetic Resonance (NMR) can be used to measure oxidative stress in patients suffering from intermittent claudication.
ID
Bron
Verkorte titel
Aandoening
Patients suffering from intermittent claudication are followed during exercise on a standard treadmill. Experiments are repeated after antioxidant suppletion (vitamins E & C).
Ondersteuning
Maxima Medical Center, Eindhoven/Veldhoven
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Levels of 'new' parameters of oxidative stress like isofuranes and halogenated phospholipids are determined. Also vascular parameters (fibrinogen, PAI-1 activity etc) and endothelial damage parameters (soluble thrombomodulin, von Willebrand factor etc) are determined. New techniques like multivariate NMR will be determined for their usefulness in the above mentioned type of studies.
Achtergrond van het onderzoek
The feasibility to use new techniques like multivariate NMR in studies on oxidative stress in vascular diseases is determined. Patients suffering from claudication intermittens are followed during exercise on a standard treadmill. Under these conditions the patients are exposed to an increased level of oxidative stress. Levels of 'new' biomarkers for oxidative stress are compared with levels of more traditional biomarkers for this condition. New techniques like multivariate NMR are examined for their usefulness in the above mentioned type of studies.
Doel van het onderzoek
Multivariate Nuclear Magnetic Resonance (NMR) can be used to measure oxidative stress in patients suffering from intermittent claudication.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Patients will receive antioxidant supplementation with high concentrations of vitamin E (200 mg/day) and vitamin C (1000 mg/day) during 4 weeks.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Stable (more than 6 months regarding subjective walking distance) patients with claudication intermittens.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients with pre-existing renal dysfunction and those not able to perform a standard walking test.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL353 |
| NTR-old | NTR392 |
| Ander register | : METC 0114 / 0112 X |
| ISRCTN | ISRCTN69086952 |