A single dose of fluoxetine influences muscle activation patterns and functional ability of the muscles in the lower part of the upper extremity in chronic stroke patients.
ID
Bron
Verkorte titel
Aandoening
Chronic (>6months) ischemic stroke.
Ondersteuning
PO Box 310
7500 AH Enschede,
The Netherlands
Tel: (+31)534875700
Fax: (+31)534340849
m.ijzerman@rrd.nl
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Muscle activation patterns, measured by EMG.
Achtergrond van het onderzoek
By conducting a cross-over, placebo-controlled study with 10 chronic stroke patients, it was found that a single dose of fluoxetine does non-selectively increase muscle activation of the upper limb in these patients. Although no equivalent effects were found for fluoxetine on motor function.
Doel van het onderzoek
A single dose of fluoxetine influences muscle activation patterns and functional ability of the muscles in the lower part of the upper extremity in chronic stroke patients.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Single administration of 20 mg of fluoxetine, or placebo.
Publiek
Rehabilitation Centre
P.O. Box 310
H.I. Genderen, van
Roessingbleekweg 33B
Enschede 7500 AH
The Netherlands
+31 (0)53 4875765
h.vangenderen@rrd.nl
Wetenschappelijk
Rehabilitation Centre
P.O. Box 310
H.I. Genderen, van
Roessingbleekweg 33B
Enschede 7500 AH
The Netherlands
+31 (0)53 4875765
h.vangenderen@rrd.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
The participating patients suffered a single ischemic stroke (confirmed by CT-scan or MRI-scan) more than six months before the start of the trial, they were over 18 years of age. Furthermore, they were able to perform some selective movements with the paretic wrist (MRC 2). And were able to follow the intructions they were given.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients suffering from an other neurological disease;
2. Uncompensated hemineglect or cognitive disabilities, resulting in misunderstanding or incapability of executing instructions given;
3. Epilepsy, or first epileptic insult poststroke;
4. Patients with first grade relatives suffering epilepsy;
5. Pregnancy;
6. Pacemaker;
7. State after irritation or lesion of median nerve;
8. Implanted pumps to administer medicines;
9. Metal parts inside the head;
10. Cerebral aneurysm-clips (metal inside);
11. Uncontrolled medical problems;
12. Alcoholism or drug-use;
13. Pathological heart rhythm disorders;
14. Raised intracerebral pressure (hydrocephalus);
15. External catheter.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL183 |
| NTR-old | NTR220 |
| Ander register | : N/A |
| ISRCTN | ISRCTN88489864 |