Patients with Type 2 diabetes who were treated with hydrochlorothiazide might be associated with an increased risk for developing skin cancer.
ID
Bron
Verkorte titel
Aandoening
Type 2 diabetes, hypertension, skin cancer
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Hazard ratio of skin cancer risk exposing to hydrochlorothiazide compared with no expose to hydrochlorothiazide
Achtergrond van het onderzoek
Hydrochlorothiazide is one of the conventional first-line antihypertensive drugs, however, its safety concern regarding its photosensitizing characteristic and risk of cutaneous squamous cell carcinoma is uncertain.
To determine the safety profile of HCTZ use regarding cSCC risk, we aim to perform a prospective cohort study of patients with type 2 diabetes using a datalink of the annual benchmarking database in Dutch primary care (Zwolle Outpatient Diabetes project Integrating Available Care [ZODIAC], 1998–2014), the Dutch National Cancer Registration, and the Dutch personal Records Database. All the eligible patients will be included and the only exclusion criteria will be those who had a history of skin cancer prior to or at baseline. Patients who were ever exposed to hydrochlorothiazide will be compared with patients who were never exposed to hydrochlorothiazide.
Doel van het onderzoek
Patients with Type 2 diabetes who were treated with hydrochlorothiazide might be associated with an increased risk for developing skin cancer.
Onderzoeksopzet
Hazard ratio will be calculated for during the maximally 18 follow-up years.
Onderzoeksproduct en/of interventie
Exposure to hydrochlorothiazide
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Type 2 diabetes patients treated in the primary care
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Type 2 diabtes patientes who had a history of skin cancer before cohort entry
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8368 |
| Ander register | university medical center groningen : METC 13.0765 |