Safety of a long-term endoscopic surveillance protocol for serrated polyposis patients

Serrated polyposis syndrome (SPS) is characterized by the presence of multiple colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. The prevalance of SPS is estimated to be 1:3000 which makes SPS more common than other polyposis syndromes such as FAP. Due to the risk of malignant polyp transformation, SPS patients undergo endscopic surveillance with removal of polyps or a surgical colonic resection. However, no uniform and adequately substantiated endoscopic management protocol exists regarding polyp removal and surveillance intervals. Earlier research from our research group showed that annual surveillance by experts is safe with regard to interval carcinomas. However annual surveillance could result in systematic overtreatment.



Aim:

To prospectively assess the efficacy, feasibility and safety of a new systemised endoscopic surveillance protocol in which colonoscopic findings will determine the following surveillance interval; one or two years.

To prospectively assess the efficacy, feasibility and safety of a renewed systemised endoscopic surveillance protocol in large multicentre HPS cohort.

5 years

Data are collected in prospective manner from patients during routine surveillance endoscopies with removal of all polyps > 3 mm and/or with a adenomatous aspect.