1. Flat adenomas are common findings in patients at average- or at high-risk for CRC; 2. Flat adenomas are characterized by a different molecular profile as compared to polypoid lesions; these molecular features are associated with an increased…
ID
Bron
Verkorte titel
Aandoening
colorectal cancer, precursor lesions, adenoma, flat, non-polypoid, high-risk population, family history of colorectal cancer
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Prevalence of flat colorectal lesions in a Dutch population;<br>
2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer);<br>
3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions;<br>
4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage);<br>
5. Relation between serrated and adenomatous polyps.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
1. Flat adenomas are common findings in patients at average- or at high-risk for CRC;
2. Flat adenomas are characterized by a different molecular profile as compared to polypoid lesions; these molecular features are associated with an increased risk for progression to CRC;
3. Serrated polyps are common findings in a population attending for routine colonoscopy.
Onderzoeksopzet
Analysis will be performed after the colonoscopy.
Onderzoeksproduct en/of interventie
1. Clinical data registration;
2. Molecular analysis of polypoid vs. flat colorectal lesions.
Publiek
E. Rondagh
Department of Gastroenterology and Hepatology
Maastricht University Medical Center
Maastricht 6202 AZ
The Netherlands
+31-43-3875021
Eveline.Rondagh@INTMED.unimaas.nl
Wetenschappelijk
E. Rondagh
Department of Gastroenterology and Hepatology
Maastricht University Medical Center
Maastricht 6202 AZ
The Netherlands
+31-43-3875021
Eveline.Rondagh@INTMED.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Molecular analysis: patients with inflammatory bowel disease.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1781 |
| NTR-old | NTR1891 |
| Ander register | Metc - Maastricht University Medical Center : MEC 08-4-074 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |