The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
ID
Bron
Aandoening
steno-occlusive disease of the vertebral and basilar artery.
Ondersteuning
Department of Radiology (HP E.01.132)
PO-Box 85500
3508 GA Utrecht
Department of Radiology (HP E.01.132)
PO-Box 85500
3508 GA Utrecht
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome is cerebrovascular reactivity measured with MR imaging at 3 Tesla using a visual stimulus and administration of vasodilatory challenge medication to induce hemodynamic stress.
Achtergrond van het onderzoek
In patients with ischaemic stroke and steno-occlusive disease of the vertebrobasilar artery it is difficult to assess which patients are at risk for future stroke and should be treated with an endovascular or surgical procedure. An important parameter that can predict such events is the cerebrovascular reactivity, the vasodilatory response of the cerebral resistance vessels. The global increase of cerebral blood flow under conditions of hemodynamic stress is a measure of the cerebrovascular reactivity.
The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
Doel van het onderzoek
The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
Onderzoeksopzet
Within one year of onset of clinical symptoms.
Onderzoeksproduct en/of interventie
No intervention is applicable.
Publiek
N.S. Hartkamp
University Medical Center Utrecht, Department of Radiology (HP E.01.132)
Utrecht 3508 GA
The Netherlands
+31 (0)88 7556687
n.s.hartkamp@umcutrecht.nl
Wetenschappelijk
N.S. Hartkamp
University Medical Center Utrecht, Department of Radiology (HP E.01.132)
Utrecht 3508 GA
The Netherlands
+31 (0)88 7556687
n.s.hartkamp@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. 18 years or older;
2. Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Pregnancy or possible pregnancy;
2. Implanted stent(s);
3. Severe liver or renal dysfunction;
4. Addison’s disease;
5. Allergic reaction for sulfonamides;
6. Cor pulmonale;
7. Longobstruction / emfysema;
8. Primary hyperaldosteronisme;
9. Fenytoïne, primidon and/or fenobarbital use;
10. Japanese and Indian subjects or subjects of Japanese descent;
11. Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2432 |
| NTR-old | NTR2541 |
| Ander register | EudraCT : 2010-022875-70 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |