Objective: The overall aim of this project is to asses the characteristic changes of the strain-volume loop, after acute, physiological-induced, changes in afterload. We hypothesize that the strain-volume loop will present a leftward shift in caseā¦
ID
Bron
Verkorte titel
Aandoening
None, we will test healthy control subjects
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary study parameter will be the slope of the systolic strain-volume relation (Sslope)
Achtergrond van het onderzoek
Recent technical developments allow monitoring of strain and volume using echocardiography. Using this information enables the production of an strain-volume loop. In this study we will investigate the relationship strain and volume in healthy controls before and after acute physiological-induced changes in afterload.
Doel van het onderzoek
Objective: The overall aim of this project is to asses the characteristic changes of the strain-volume loop, after acute, physiological-induced, changes in afterload. We hypothesize that the strain-volume loop will present a leftward shift in case of a reduced afterload and a rightward shift in case of an increase afterload.
Onderzoeksopzet
na
Onderzoeksproduct en/of interventie
To induce the changes in afterload we will use two different interventions:
To
reduce the afterload (and preload) we will use vasodilative medication (vasodilatorĶ¾ nitroglycerine), which will primary reduce
the peripheral vascular resistance.
To
increase the afterload we will use anti gravity jeans to occlude the blood supply of the legs for 2 minutes (transient atrial
occlusion), which will cause a increase in the peripheral vascular resistance.
Publiek
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Wetenschappelijk
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age between 18 and 30 or above 60
- Male gender
- Mentally competent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- History of cardiovascular diseases
- Diabetes Mellitus
- Use of medication or other substances which influences the cardiovascular system
- Contraindications for the usage of sublingual nitroglycerin
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5975 |
| NTR-old | NTR6349 |
| Ander register | : 2017-3166 |