Dried Blood Spot is a reliable method to determine antipsychotic blood levels.
ID
Bron
Verkorte titel
Aandoening
antipsychotics, pipamperone, aripiprazole, paliperidone, risperidone
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study parameter is the agreement between antipsychotic drug plasma levels of blood collected by venipuncture or DBS, both measured by ultra-performance liquid chromatography tandem mass-spectrometry (UHPLC-MS/MS)
Achtergrond van het onderzoek
The advantages in of the new Dry Blood Spot (DBS) method have been recognized for use in TDM. DBS allows drug monitoring in a home setting with a single fingerprick, which is less invasive, painful and stressful. A DBS method for determination of the mostly prescribed antipsychotics risperidone, pipamperone and aripiprazole has been developed. The objective of this study is to clinically validate this method. 20 patients per drug will undergo a DBS fingerprick and venipuncture simultaneously. The two measurements will be compared using Deming regression and Bland Altmand plots.
Doel van het onderzoek
Dried Blood Spot is a reliable method to determine antipsychotic blood levels.
Onderzoeksopzet
only one measurement
Onderzoeksproduct en/of interventie
Participants will undergo one fingerprick and venipuncture which will cause mild local irritation.
Publiek
B.C.P. Koch
‘s Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31(0)10-7040704
b.koch@erasmusmc.nl
Wetenschappelijk
B.C.P. Koch
‘s Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31(0)10-7040704
b.koch@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- using either aripiprazole, risperidone, paliperidone or pipamperone
- ≥ 18 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
none
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6339 |
| NTR-old | NTR6655 |
| Ander register | METC van het Erasmus MC / toetsingonline (CCMO) : MEC-2016-123 / NL57233.078.16 |