What does the non-specific cytokine response contribute to the prediction of prosthesis fixation (expressed in MTPM after 1 year), compared with simple patient characteristics?
ID
Bron
Verkorte titel
Aandoening
Innate Immunity
Radio Stereometric Analysis
Aseptic Loosening
Knee Replacement Arthroplasty
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Maximum Total Point Motion at 1 year, measured by RSA;<br>
2. PAM3Cys and LPS-stimulated cytokine profiles.
Achtergrond van het onderzoek
Aseptic loosening is the most common cause of failure of current joint
replacement arthroplasties in the long term (>10 years after index
surgery). Wear particles cause a sterile periprosthetic inflammatory
process, which leads to osteolysis and formation of fibrous tissue.
Pro-inflammatory cytokines play a major role in this process.
Micromotion preceeds aseptic loosening and can be accurately measured by
RSA. RSA measurements can only be performed if tantalum markers are
inserted during surgery.
Innate immunity can be determined at any time, even pre-operatively.
Innate immunity may even be a useful tool in predicting the preoperative
risk of aseptic loosening.
Doel van het onderzoek
What does the non-specific cytokine response contribute to the prediction of prosthesis fixation (expressed in MTPM after 1 year), compared with simple patient characteristics?
Onderzoeksopzet
Patients will undergo a single venipuncture, to obtain 32ml of blood.
Onderzoeksproduct en/of interventie
N/A
Publiek
J.C. Keurentjes
Albinusdreef 2, Room J-09-127
Leiden 2300 RC
The Netherlands
+31 (0)71 526 1566
j.c.keurentjes@lumc.nl
Wetenschappelijk
J.C. Keurentjes
Albinusdreef 2, Room J-09-127
Leiden 2300 RC
The Netherlands
+31 (0)71 526 1566
j.c.keurentjes@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients over 18 years, who underwent elective knee replacement arthroplasty;
2. Patients who are part of an RSA-cohort and whose MTPM at 1 year have been measured.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. No measurable MTPM at 1 year, or inadequate registration;
2. Tibia component in frontal plane greater than 5 ° varus or valgus 5.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2081 |
| NTR-old | NTR2197 |
| CCMO | NL30892.058.09 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON32587 |