In patients with end-stage heart failure (NYHA class III or IV, LVEF 120 ms, LBBB), the dyssynchrony of the left ventricle is the most important predictor of clinical benefit. The dyssynchrony of the left ventricle can be assessed (at any time…
ID
Bron
Verkorte titel
Aandoening
Patients with end-stage heart failure
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To develop non-invasive selection criteria (using echocardiography) to identify patients with end-stage heart failure who are likely to benefit from biventricular pacing.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
In patients with end-stage heart failure (NYHA class III or IV, LVEF <35%, QRS duration >120 ms, LBBB), the dyssynchrony of the left ventricle is the most important predictor of clinical benefit.
The dyssynchrony of the left ventricle can be assessed (at any time before implantation) non-invasively by Tissue Doppler Imaging(TDI).
Thus, information on dyssynchrony derived from TDI may predict clinical benefit from biventricular pacing (BVP).
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Patients will undergo BVP implantation based on traditional selection criteria. VO2 max and TDI will be performed before and 3 months after BVP implantation. From these patients the TDI criteria which optimally predict clinical improvement (in VO2 max) will be derived.
Publiek
Department of Cardiology,
P.O. Box 9600
J.J. Bax
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262020
j.j.bax@lumc.nl
Wetenschappelijk
Department of Cardiology,
P.O. Box 9600
J.J. Bax
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262020
j.j.bax@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Severe heart failure (NYHA class III or IV);
2. Severely depressed left ventricular ejection fraction (LVEF <35%);
3. QRS exhibiting left bundle branch block configuration with a duration >120 ms.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
N/A
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL442 |
| NTR-old | NTR482 |
| Ander register | : N/A |
| ISRCTN | ISRCTN09353557 |