Reduced tremor power during transcranial alternating current stimulation over primary motor cortex (at tremor frequency and phase-locked to the ongoing tremor).
ID
Bron
Verkorte titel
Aandoening
English: Dystonic tremor, Dystonia, Essential tremor, tacs
Dutch: Tremor bij Dystonie, Dystonie, Essentiële tremor, tacs, beven
Ondersteuning
Kapittelweg 29 6525 EN Nijmegen
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1) phase specific tremor power suppression during M1 tacs, in ET vs DT<br>
2) phase specific tremor power suppression during Cerebellar tacs, in ET vs DT<br>
3) Phase specific tremor related cerebral activity during cerebellar tacs, in ET vs DT
Achtergrond van het onderzoek
“In this study we will investigate whether frequency and phase specific transcranial alternating current stimulation (TACS) over the primary motor cortex and cerebellum influences tremor in dystonia and essential tremor. Outcome measures are tremor power (based on accelerometry) and tremor related cerebral activity and connectivity (combined TACS-fMRI). In addition, we will study the cerebral mechanisms underlying tremor in both disorders by using combined EMG-fMRI and GABA-MRS.”
Doel van het onderzoek
Reduced tremor power during transcranial alternating current stimulation over primary motor cortex (at tremor frequency and phase-locked to the ongoing tremor).
Onderzoeksopzet
Not applicable, 2 visits for each participant, outcome measures divided over the two days.
Onderzoeksproduct en/of interventie
Transcranial alternating current stimulation (tacs) over primary motor cortex and cerebellum at tremor frequency and phase locked to ongoing tremor (as measured with accelerometry).
Stimulation during 20 blocks of 30s, at 18 degree phase difference increments around the phase circle (random ordering, phase difference between ongoing tremor and tacs).
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Essential tremor:
-Clinical diagnosis of essential tremor
-Postural tremor of both hands
-Onset of tremor before the age of 65
Dystonic tremor:
-Clinical diagnosis of dystonic tremor
-Primary focal / segmental dystonia
-Presence of postural tremor of at least one arm (which may or may not be the dystonic limb)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
-Neurological co-morbidity
-Moderate to severe head tremor (to avoid artifacts caused by extensive head motion during scanning)
-Cognitive dysfunction (clinical diagnosis of mild cognitive impairment or dementia)
-Considerable diagnostic doubt between essential and dystonic tremor (no consensus reached in team meetings neurologists or considerable doubt in medical record).
-Use of anti-tremor medication other than propranolol
-Any contraindications for MRI or transcranial stimulation (e.g. non compatible metal implants, epilepsy, active implants).
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6686 |
| NTR-old | NTR6856 |
| Ander register | NL60335.091.17 : HA2016-02-01 |