Migraine patients, compared with healthy volunteers, have more subclinical cerebellar dysfunctions, measured by the eye-blinker.
ID
Bron
Verkorte titel
Aandoening
engels: migraine, headache, eyeblink, cerebellum, sway-test
nederlands: migraine, oogknipper, cerebellum, sway-test
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The conditioning as measured with eyeblink between migrainepatients and controls.
Achtergrond van het onderzoek
Earlier examinations possibly shows small damage of the cerebellum in patients with migraine, especially in patients with aura. These defects are structural as well as functional. It is also shown that conditioning largely takes place in the cerebellum. The eye-blinker is a valid method to measure conditioning. The Sway-test is a good methode to measure the coordination and to detect minimal movements.
This study will examine the difference in conditioning between patients with migraine en healthy volunteers.
Doel van het onderzoek
Migraine patients, compared with healthy volunteers, have more subclinical cerebellar dysfunctions, measured by the eye-blinker.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
The difference in the conditioning, between migraineurs and healthy volunteers,
is measured by using the eyeblinker. The technique is called the chip-MDMT
(Magnetic Distant Measurement Technique). A magnet will be placed on the right eyelid. A sensor will be placed below the right eye. So the length, the power and the time of each blink is measured. The test will consist of 8 trials of 6 minutes. A conditioned respons will be generated by using airpuffs and tones.
Publiek
P.O. Box 9600
W. Brekelmans
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+ 31 71-5261730
w.brekelmans@umail.leidenuniv.nl
Wetenschappelijk
P.O. Box 9600
W. Brekelmans
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+ 31 71-5261730
w.brekelmans@umail.leidenuniv.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with migraine and aura with minimal 6 attacks a year (2 with aura);
2. Healthy volunteers without migraine;
3. Patients with a cerebellar degenerative diseases.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
For the migrainepatients and healthy controls:
1. Neurologic diseases in which the function of cerebellum is disturbed;
2. The use of medicines/drugs which have influence on the coordination 24 hours before taking part of this examination.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL914 |
| NTR-old | NTR938 |
| Ander register | : N/A |
| ISRCTN | ISRCTN94004433 |