T-cell inflammation in the vascular wall of an asymptomatic intracranial aneurysm can be accurately detected with 18F-IL2 PET-CTA (proof-of-concept).
ID
Bron
Verkorte titel
Aandoening
Unruptured intracranial aneurysm
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Prediction of inflammation by 18F-IL2 PET-CTA, related to the gold standard of histopathological examination (proof-of-concept).
Doel van het onderzoek
T-cell inflammation in the vascular wall of an asymptomatic intracranial aneurysm can be accurately detected with 18F-IL2 PET-CTA (proof-of-concept).
Onderzoeksopzet
None
Onderzoeksproduct en/of interventie
18F-IL2 PET-CTA
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age > 18 year
- Presence of an unruptured intracranial aneurysm
- Standard of care decision to treat the aneurysm
- The aneurysm is surgically accessible
- Aneurysm wall sampling is deemed possible by the surgeon
- Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Prior therapy on the targeted unruptured intracranial aneurysm
- Presence of intracranial neurovascular disorders, other than intracranial aneurysms
- Contra-indications to general anesthesia or craniotomy
o Thrombocytopenia (<100,000/µL)
o Uncorrectable coagulopathy (INR >1.5)
- Contra-indications to 18F-IL2 PET-CTA
o Technical impairments to perform the study
Incapacity to lie still for 30 minutes
Physical restrictions, e.g. morbid obesity
Claustrophobia
o Pregnancy or lactation
o Renal insufficiency (estimated glomerular filtration rate < 60 ml/min/1.73 m2)
o Known allergy to iodine contrast agent
o Treatment with metformine
o Morbus Kahler / M. Waldenstrom
o Myasthenia gravis
o Pheochromocytoma
o Mastocytosis
o Thyroid cancer
o Planned thyroid scan
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4922 |
| NTR-old | NTR5024 |
| Ander register | 201500130 : UMCG |