1. Advanced neuroimaging, in combination with standard MRI, will have a superior diagnostic accuracy in comparison with standard MRI alone. 2. Histological and molecular characteristics of glioma will correlate better with advanced imaging than…
ID
Bron
Verkorte titel
Aandoening
EN: glioma
NL: glioom
Ondersteuning
Dutch Cancer Society (OAA/H1/VU 2015-7502)
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Qualitative (high, normal or low signal) and quantitative parameters of MRI and PET for each biopsy site <br>
- Qualitative (central glioma, glioma infiltration, normal brain or uninformative) histopathological score of each biopsy site
Doel van het onderzoek
1. Advanced neuroimaging, in combination with standard MRI, will have a superior diagnostic accuracy in comparison with standard MRI alone.
2. Histological and molecular characteristics of glioma will correlate better with advanced imaging than standard imaging.
Onderzoeksopzet
Phase I (n=8) 12 months
Phase II (n=12) 12 months
Phase III (n=20) 12 months
Onderzoeksproduct en/of interventie
Observational study with PET and MRI previous to stereotactic biopsies in and around the tumor.
Publiek
P.C.
de Witt Hamer
P.O. Box 7057
1007 MB
Tel: (+31) 204443783
Wetenschappelijk
P.C.
de Witt Hamer
P.O. Box 7057
1007 MB
Tel: (+31) 204443783
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients of 18 years and older with a MRI interpretation by an expert neuroradiologist of a diffuse infiltrative glioma, and who have an indication, confirmed by the multidisciplinary neuro-oncology tumor-board, for resective surgery.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients who are pregnant or underwent previous brain surgery, cranial irradiation or chemotherapy. Patients with other brain pathology on MRI, such as stroke or multiple sclerosis. Patients with a tumor located infratentorially or in the spinal cord.
Withdrawal criteria
Patients who do not successfully undergo one PET scan in phase I and III or both PET scans in phase II.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5205 |
| NTR-old | NTR5354 |
| Ander register | METC : 2013/335 |