We expect brain activity and brain reactivity to change as satiation progresses. ROI are : Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus, Insula, overlying operculum, secondary:…
ID
Bron
Verkorte titel
Aandoening
Overeating, obesity, overweight
over eaten, obesitas, overgewicht
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Differences in brain activity in rest and in reactivity (BOLD signal) upon oro-sensory exposure to food, between hungry and progressive satiated states. <br>
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Regions of interest (ROI) are:<br>
• Satiation: Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus<br>
• Taste perception: primary: Insula, overlying operculum, secondary: orbitofrontal cortex, Thalamus<br>
• Reward: striatum (nucleus accumbens, Putamen), amygdala, Hippocampus, Midbrain (Ventral tregmental area (VTA), substantia nigra), medial pre frontal cortex.<br>
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In addition to these ROI we are interested in brain activity networks (functional connectivity).
Achtergrond van het onderzoek
Objective: The objective of this study is to determine differences in resting state brain activity and brain reactivity to taste, between hungry and progressive satiated states, with a focus on activity within the brainstem.
Study design: The study has a within subject repeated-measures experimental study design and consists of one test day.
Study population: Forty, right-handed healthy adults between 18-35 years old with a BMI between 18.5-27 kg/m2 will be included.
Intervention: We will measure resting state brain activity and brain reactivity to chocolate milk using fMRI, in a hungry state, a 50% sated state and a 100% sated state. To arrive at the 50% and 100% satiated states, subjects will be asked to drink chocolate milk between scanning blocks.
Main study parameters: Differences in brain activity in rest and brain reactivity (BOLD response) upon oro-sensory exposure to food, between hungry, 50% and 100% sated states (3 repeated measures). The secondary outcome of this study is stomach filling (ml) measured by MRI at 4 time points (hungry, at the beginning and end of the 50% sated state MRI measure, and once during the 100% sated state MRI measure).
Doel van het onderzoek
We expect brain activity and brain reactivity to change as satiation progresses. ROI are : Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus, Insula, overlying operculum, secondary: orbitofrontal cortex, Thalamus striatum (nucleus accumbens, Putamen), amygdala, Hippocampus, Midbrain (Ventral tregmental area (VTA), substantia nigra), medial pre frontal cortex.
Onderzoeksopzet
hungry state, 50% sated state, 100% sated sate
Onderzoeksproduct en/of interventie
This study investigates changes in brain responses as satiation progresses. In order to study this we will measure resting state brain activity and brain reactivity to taste in 1) a hungry state, 2) a 50% sated state and 3) a 100% sated state within each subject.
Publiek
Marlou Lasschuijt
Biotechnion, Building 307, Room 107B
Wageningen
The Netherlands
tel +31 317 484586
marlou.lasschuijt@wur.nl
Wetenschappelijk
Marlou Lasschuijt
Biotechnion, Building 307, Room 107B
Wageningen
The Netherlands
tel +31 317 484586
marlou.lasschuijt@wur.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Right handed (Left and right handed people show differences in brain activation when tasting)
• Between 18-35 years old at the day of inclusion
• Able to understand and speak English fluently or without difficulty (self-report)
• BMI 18.5-27 kg/m2
• Good general health and appetite (see F1 questionnaire self-report)
• Willing to comply with the study procedures
• Agrees on being informed about incidental findings of pathology through his general practitioner
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Failing to meet one or more of the inclusion criteria
• Women: being pregnant, having the intention to become pregnant within half a year.
• Women: using a IUD as anti-conceptive ( with exception of the Mirena IUD which is MRI safe).
• Having difficulties with tasting, smelling, swallowing or eating in general.
• Suffering from a neurological, endocrine, or eating disorder, gastrointestinal or mental illness or illness of the thyroid gland, respiratory disease or diabetes.
• Having sight (except glasses) or hearing disorder (self-report)
• Having non-removable dental braces (with the exception of a dental wire)
• Smoking: smoking on average one or more cigarettes/cigars a day
• Having a history of, or current alcohol consumption of, drinking on average more than 21 units per week (cut-of based on ref (50))
• Not willing to stop using drugs during the study period (from inclusion till test session)
• Use of medication that may influence study outcomes (self-report, see F1 questionnaire)
• Allergies or intolerance to any ingredient of the test foods.
• Not willing to eat the test food/drink because of eating habits or believes.
• Followed an energy restricted diet during the last 2 months
• Gained or lost 5 kg of body weight over the last half year
• High restrained eater according to the Dutch Eating Behaviour Questionnaire
• Participating in another research study
• Employee of Human Nutrition department of Wageningen university
• Thesis student or intern at the chair group of Sensory Science and Eating Behaviour Human Nutrition (WUR).
• not having a general practitioner
• Intensive exercising more than 8 hours per week
• Low score ( 4, neutral) for liking the test food on a nine point likert scale*
MRI related exclusion criteria:
• Not willing to be in an MRI scanner
• Claustrophobic (self-report)
• Having a contra-indication to MRI scanning (including, but not limited to):
• Pacemakers and defibrillators
• Epilepsy or family history of epilepsy
• Intraorbital or intraocular metallic fragments
• Ferromagnetic implants
• Presence of non-removable piercings
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL7034 |
NTR-old | NTR7239 |
Ander register | Medical Ethical approval number : ABR 65187 |