Physical exercise is not only beneficial for general health, but has also been shown to improve brain function (cognition) and influence brain structure (increase brain volume, especially in the hippocampus). However, the underlying neural…
ID
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Verkorte titel
Aandoening
Healthy volunteers are used to elucidate the biological processes underlying the effects of exercise on the brain. This could in the future be of possible benefit for patients with neurodegenerative disorders, depression, dementia.
NL: Neurodegeneratieve stoornissen, dementie, depressie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- 1.28 ppm peak concentration in hippocampus, to assess neurogenesis (1H-MRS)<br>
- new vascularization (rCBV in hippocampus using contrast-enhanced MRI)<br>
- pattern separation
Doel van het onderzoek
Physical exercise is not only beneficial for general health, but has also been shown to improve brain function (cognition) and influence brain structure (increase brain volume, especially in the hippocampus). However, the underlying neural mechanisms that cause this increase in volume are relatively unknown. Animal studies have shown that physical exercise can increase the formation and survival of new neurons, a process called neurogenesis. In addition, these new neurons are involved in cognition, especially in hippocampal-dependent pattern separation. We hypothesize that exercise could also increase neurogenesis in the human hippocampus. The recently developed and validated non-invasive magnetic resonance spectroscopy (MRS) now allows to reliably detect neurogenesis for the first time in the live human brain.
Exercise has also been demonstrated to influence the formation of new blood vessels (angiogenesis) in the hippocampus in rodents, a process which is closely linked to neurogenesis. Angiogenesis can be measured in the human brain by contrast-enhanced MRI, exploiting the leakiness of new vessels. In this study, we aim to study the effect of exercise on neurogenesis and angiogenesis and elucidate the link to brain function in the hippocampus.
Onderzoeksopzet
All measurements at baseline (week 0) and then again after 3 months of exercise (week 12-13).
Onderzoeksproduct en/of interventie
Aerobic exercise intervention
Those subjects randomized to the aerobic exercise group will undergo a 12-week exercise program, in which they will engage in 45 minutes of aerobic exercise 3x weekly. Every two weeks the researchers will contact the subjects and will administer questionnaires.
Control exercise intervention
Those subjects randomized to the control group will undergo a 12-week exercise program, in which they will engage in 45 minutes of stretching and toning exercise 3x weekly. Every two weeks the researchers will contact the subjects and will administer questionnaires.
Publiek
Liesbeth Reneman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5668312
l.reneman@amc.uva.nl
Wetenschappelijk
Liesbeth Reneman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5668312
l.reneman@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age 18-30 years, BMI < 30 kg/m2, stable exercise history 3 months prior to study inclusion.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
current intensive sports (>3 times/week), excessive smoking (>1 pack/day), alcohol (>21 units/week), or other regular drug use, history of chronic renal insufficiency, prior allergic reaction to Gadolinium-containing compounds, psychiatric disorders and general contraindications for MRI.
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5847 |
| NTR-old | NTR6026 |
| CCMO | NL55943.018.15 |
| OMON | NL-OMON43536 |