Een "systeem biologische aanpak" kan nieuwe diagnostische markers en oorzakelijke immuunprocessen identificeren bij patiënten met artritis psoriatica.
ID
Bron
Verkorte titel
Aandoening
psoriasis; artritis psoriatica; psoriatic arthritis; spondylartropathie; morbus bechterew; reactive artritis; reactive arthritis; inflammatory-bowel-disease-geassocieerde artritis; inflammatory-bowel-disease- associated arthritis; ankylosing spondylitis; spondyloarthritis.
Ondersteuning
Pfeizer deel-sponsor.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- diagnose (artritis psoriatica versus psoriasis)
Achtergrond van het onderzoek
Objective: The primary objective is to identify molecular signatures that can serve as diagnostic and/or severity-of-disease markers for PsA and markers that can predict treatment response in patients with PsA. The secondary objective is to elucidate the underlying pathways in the development of PsA with the aim of discovering novel therapeutic targets.
Study design: Longitudinal observational study, where blood samples and clinical parameters will be prospectively collected for a maximum duration of five years per patient, and the data will be analysed using the systems biology approach.
Study population: Patients aged 18 - 75 years old with psoriasis (n=300), PsA (n=300), and a group of non-PsA spondyloarthritis (n=300, including ankylosing spondylitis, inflammatory bowel disease associated arthritis, reactive arthritis, or undifferentiated spondyloarthritis) in the out-patient clinics of the dermatology and rheumatology department.
Intervention: not applicable
Main study parameters/endpoints: Diagnosis, disease activity, and treatment response.
Doel van het onderzoek
Een "systeem biologische aanpak" kan nieuwe diagnostische markers en oorzakelijke immuunprocessen identificeren bij patiënten met artritis psoriatica.
Onderzoeksopzet
1-3x per jaar
Onderzoeksproduct en/of interventie
Geen
Publiek
University Medical Centre Utrecht <br>
P.O.Box 85090
E.F.A. Leijten
Lundlaan 6, 3508 GA, WKZ KC 02.084.2
[default]
The Netherlands
+31 (0)887553215
eleijte2@umcutrecht.nl
Wetenschappelijk
University Medical Centre Utrecht <br>
P.O.Box 85090
E.F.A. Leijten
Lundlaan 6, 3508 GA, WKZ KC 02.084.2
[default]
The Netherlands
+31 (0)887553215
eleijte2@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- The patient is age 18 - 75 years of age.
- For Population 1: a diagnosis of psoriasis made by a dermatologist
- For Population 2: a diagnosis of PsA according to CASPAR criteria and not yet treated with DMARDs or Biologicals
- For Population 3: a diagnosis of PsA according to CASPAR criteria and treated with DMARDs and/or Biologicals
- For Population 4: a diagnosis of SpA made by a rheumatologist, where the SpA is caused by an alternative disease than PsA, namely: ankylosing spondylitis (AS), inflammatory bowel disease associated arthritis, reactive arthritis, or undifferentiated spondyloarthritis.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- The patient is age 17 years or younger
- The patient is age 76 years or older
- The patient has an alternative inflammatory rheumatological diagnosis (e.g. RA, gout, pseudo-gout).
- For Population 2: past or current treatment with DMARDs or Biologicals.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4508 |
| NTR-old | NTR4626 |
| Ander register | METC UMC Utrecht : 13-696/M |