It is predicted that pretreatment with memantine can prevent the memory impairment that is usualy caused by MDMA.
ID
Bron
Verkorte titel
Aandoening
MDMA incuded memory impairment
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Memory performance is the primary outcome and is measured immediately after each cannabis/placebo treatment. Memory is measured with a verbal memory test and a prospecitve memory test.
Achtergrond van het onderzoek
Previous studies showed that ecstacy (MDMA) affects cognitive performance, such as memory. Animal studies have shown that memantine, a drug used in the treatment of alzheimer patients, can prevent the memory problems caused by ecstacy.
This will be a double blind, placebo controlled, 4-way cross over design. Subjects will be pretreated with placebo or memantine. Two hours later they will be treated with placebo or MDMA. In between test days, a wash-out period of at least a week will be respected.
Doel van het onderzoek
It is predicted that pretreatment with memantine can prevent the memory impairment that is usualy caused by MDMA.
Onderzoeksopzet
Subjects will be pretreated with placebo or memantine. Two hours later they will be treated with placebo or MDMA.
Onderzoeksproduct en/of interventie
1. Placebo - Placebo;
2. Memantine 20 mg - Placebo;
3. Placebo - MDMA 75 mg;
4. Memantine 20 mg - MDMA 75 mg.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Recreational MDMA users;
2. Age between 18 and 40 years;
3. Free from psychotropic medication;
4. Good physical health;
5. Absence of any major medical, endocrine and neurological condition;
6. Normal weight;
7. Written Informed Consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of drug abuse (other than the use of MDMA) or addiction;
2. Pregnancy or lactation;
3. Excessive drinking;
4. Hypertension;
5. Current or history of psychiatric disorder.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2664 |
| NTR-old | NTR2792 |
| Ander register | MEC Maastricht University : 11-3-007 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |