Monitoring van indirecte allorecognitie in niertransplantatieontvangers

Inclusion criteria for renal transplant patients:
• Age: 18 - 80 years
• Female or male
• First kidney transplantation (living and cadaveric)
• Patients must be able to give informed consent and the consent must be obtained prior to any study procedure.
• Patients must be transplanted with an HLA-A1, A2, B7 and/or B8 mismatched kidney. (Recipients must therefore have at least one mismatch with one of the previously mentioned HLA-I)
• At least 6 months after transplantation

Exclusion criteria for renal transplant patients:
• Double organ transplantation.
• Patients with a previous transplantation since the earlier mismatch might complicate interpretation.
• Patients who had a rejection episode less than 2 months before.
• Patients with evidence of active infection or abscesses
• Patients suffering from an active autoimmune disease
• Subjects who currently have an active opportunistic infection (e.g., herpes zoster [shingles], cytomegalovirus (CMV), Pneumocystis carinii (PCP), aspergillosis, histoplasmosis, or mycobacteria other than TB)
• Malignancy (including lymphoproliferative disease) within the past 2-5 years (except for squamous or basal cell carcinoma of the skin that has been treated with no evidence of recurrence).