721 resultaten
To test the safety and preliminary efficacy of a dual acute thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of HisproUK against usual treatment with IV alteplase in patients presenting with…
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato…
It is hopthesized that a multidimensional implementation approach with multiple interventions integrated in the usual care will improve physical behaviour during hospitalization
Neutralizing antibody titers after fractional dosing of yellow fever vaccine are comparable to standard dose vaccination, ten years after primary vaccination
Kidney transplantation is the only treatment offering long-term benefit to patients with chronic kidney failure. Urological complications after kidney transplantation, such as urinary leakage and ureteral strictures, are associated with significant…
Patient education on extended anticoagulation pros and cons: a journey app in venous thromboembolism
Our hypothesis is that patients whom receive targeted information about VTE and (extended) anticoagulation treatment with the 'patient journey app' on a daily basis in the week preceding their hospital visit will be more satisfied with the…
It is hypothesised that compared to waiting list control condition, participants in the intervention improve their diet and physical activity on the short (6 months after baseline) and long-term (12 months after baseline; when the participant…
What is the influence of protective gear on the performance of basic life support (BLS) by KNRM lifeboat crewmembers during a manikin simulation training
Primary hypothesis is that MRDTI will demonstrate acceptable sensitivity and specificity for the diagnosis of acute SVT and the differentiation between acute and chronic SVT.
The hypothesis states that the time tom complete an emergency airway with Cricath device is significant faster than with Quicktrach device, which will be studied on porcine cadaver models. In the second outcome, the hypothesis states that there is…
Fatigue is expected to be the most prevalent symptom in patients with ILD (IPF and sarcoidosis), next to dyspnoea. Frequency of moderate to severe fatigue in patients with ILD is unknown. In addition, possible correlates of fatigue, including age,…
In the proposed study we will investigate the effect
Pre-hospital triage in patients with low risk of NSTE-ACS will reveal a large saving in health care resources in favor of the pre-hospital rule strategy with additional GP management. At 12 months the strategy will corroborate with a very low event…
To investigate whether myocardial blood volume (MBV) is reduced in patients with non-obstructive coronary artery disease and signs and symptoms of ischemia, relative to healthy controls. The specific aims are to investigate 1) if MBV is reduced in…
To determine the presence or absence of central sensitisation in patients with Chronic Low Back Pain with radiation to the leg (CLBPr) and to determine the effect of segmental nerve interventions on central sensitisation.
The main objective of this study is to investigate which communicative strategies are most effective in increasing understanding and decreasing emotional impact in communicating increased risk for developing dementia status to persons with mild…
The primary hypothesis is that playing the serious game 'You & I' will be associated with an improvement of the mentalizing abilities in adults with mild to borderline intellectual disabilities. The secondary hypothesis is that…
Poor glycaemic control, indicated by an elevated HbA1c, is correlated to poor postoperative outcome in patients with diabetes mellitus undergoing surgery. However, improving glycaemic control before surgery has not been extensively studied so far.…
If there is a correlation between liking by smelling and liking by vaping, future experiments on e-liquid flavors would require smelling experiments only.
• To evaluate the safety and tolerability of three oral dose levels of LTI-291 following 28 days of LTI-291 treatment in patients with Parkinson’s Disease with GBA-PD. • To characterize the plasma and CSF pharmacokinetics (PK) of LTI-291 following…