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Prevention of Depression and Anxiety in Adolescents with a High Familial Risk.

The effectiveness of an indicated indicated depression and anxiety prevention program ('Een Sprong Vooruit') will be tested in a Dutch sample of adolescents (aged 11-15) with high familial risk. It is expected that the adolescents who…

Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder.

Information-processing: 1. Changes in measures of severity of OCD are explained (partially) by changes in measures of meta-cognitions (explicit and/or implicit); 2. Changes in measures of meta-cognitions (explicit and implicit) precede changes in…

Thuis in de opvang: Een fijne start voor baby’s

The intervention will result in: - higher observed sensitivity and more positive attitudes towards sensitive caregiving in professional caregivers - lower cortisol levels, higher wellbeing and more attachment security in infants - less separation…

A Randomized Trial comparing Surveillance with Radio-Frequency Ablation of Barrett’s Esophagus with Low-Grade Dysplasia; the SURF-study.

Radiofrequency ablation (RFA) will lead to permanent and complete eradication of Barrett's epithelium. This will prevent development of high grade intraepithelial neoplasia (HGIN) or early carcinoma and may eliminate the need for endoscopic…

SUstainable PREvention of cardioMEtabolic risk through NUDGing hEalth behaviors

Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.

Randomized study with a run-in dose-selection phase to assess the added value of lenalidomide in combination with standard remission-induction chemotherapy and post-remission treatment in patients aged 18-65 years with previously untreated acute myeloid leukemia (AML) or high risk myelodysplasia (MDS) (IPSS-R risk score > 4.5)

The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.

Prodromal symptoms and early intervention to prevent a relapse.

Could early treatment of prodromal symptoms prevent or postpone a psychotic relapse in schizophrenia?

Patient Safety and Complex Care.

The rate of unintended events and avoidable harm for elderly hip fracture patients can be reduced by the introduction of three integrated interventions directed at the structure of the handover process, the role of the patient in the care process…

Mechanical bowel preparation for elective colorectal surgery.

Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.

A Phase II randomized multicenter study to assess the efficacy of lenalidomide with or without erythropoietin and granulocyte-colony stimulating factor in patients with low and intermediate-1 risk myelodysplastic syndrome.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

The (cost-) effectiveness of an internet intervention for eating disorders.

1. The intervention is effective in reducing eating disorder symptoms; 2. There is an incremental effect of intensive/frequent support from a coach in terms of reducing ED symptoms.

Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.

N/A

An open randomised study comparing efficacy of maintenance therapy with imiglucerase at a frequency of once every four weeks versus the original schedule (once every one or two weeks) in adult type I Gaucher disease patients.

To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…

Lifestyle Interventions for Severe Mentally Ill Outpatients in the Netherlands.

1. A multidimensional lifestyle intervention, including aspects of increased awareness, motivation, self-management, diet, exercise, and a supportive environment, improves or prevents deterioration of the cardiometabolic risk factors of SMI…

Radiostereometric analysis as early predictor for aseptic loosening of the femoral component in total hip arthroplasty: A double meta-analysis.

The aim of the meta-analysis is to investigate the early predictive value of migration measured by RSA 1 year post-operatively for revision for aseptic loosening of the femoral component in THA and to compose migration thresholds for safe and…

Anti-TNF-alpha (Infliximab) in Complex Regional Pain Syndrome.

Infliximab counteracts the increased synthesis of tumor necrosis factor alpha (TNF-alpha), after which inflammation will decrease and recovery of the disease occur.

Elective laparoscopic appendectomy for chronic right lower abdominal pain;
outcome of a prospective randomised
double-blind controlled surgical trial.

Elective laparoscopic appendectomy is a usefull procedure in patients with chronic or recurrent right lower abdominal pain.

Phase II trial of combination therapy with oxaliplatin and capecitabine in patients with advanced esophageal cancer.

For patients with metastatic or local-regional unresectable esophageal carcinoma there is no alternative treatment. In this trial it is studied whether combination chemotherapy with oxaliplatin and capecitabine prolongs survival and improves quality…

Posture or Patching (PoP).
Accelerated clearing of the media with massive vitreous hemorrhage and suspected retinal tear.

Binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants following a vitreous hemorrhage.

SC.20 / CKTO 2004-06
A phase III international randomised trial of singel versus multiple fractions for re-irradiation of painful bone metastases.

To study the effectivity of different retreatment radiotherapy schedules for painful bone metastases.