173 resultaten
1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressions. Unfortunately, several cognitive side effects with a large pallet of different manifestations and impact often occur. For instance, postictal agitation ((PIA)…
To assess the impact of the physical form of five different cocoa matrices on the bioavailability of the monomeric flavan-3-ols.
Microalbuminuria in diabetes mellitus is not only associated with progression to renal disease, it is also a potent predictor of cardiovascular disease and thus may reflect widespread vascular damage. Endothelial dysfunction is one of the first…
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…
Long-chain triglyceride (LCT) emulsions with di-unsaturated fatty acids will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with mono-unsaturated or saturated fatty acids.
We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…
Het effect onderzoeken van acute verhoging van groeihormoon waardes op cognitief functioneren in gezonde mensen, en uitvinden of de relatie tussen groeihormoon en cognitie direct of indirect is. Doel van het onderzoek: We willen de acute effecten…
1: Blockade of the angiotensin II AT1-receptor improves the insulin-induced microvascular effects in hypertensive patients. 2: Blockade of the angiotensin II AT1-receptor impairs the insulin-induced microvascular effects in normotensive control…
We hypothesize that methylphenidate improves ADHD manifestations in adults with (late-diagnosed) PKU.
We hypothesized that adding alimemazine to existing ADHD treatment will decrease ADHD-symptoms as reported by parents and school teachers as well as allergic symptoms.
The purpose of this study is to investigate the effect of recorded music on surgical task performance and mental workload in a simulated setting. The study hypothesis is that preferred music will improve surgical task performance and decrease mental…
Due to the lack of information about DON absorption and excretion, the aims of this study are the description of the DON and metabolites excretions patterns and know the absorption and excretion rates of it. Moreover, the results can be useful to…
To investigate whether uridine (Urd) area under the curve (AUC) and Cmax of product B is equivalent to the Urd AUC and Cmax of product A
Healthy volunteers and patients with a high variability in pain scores have a high probability to experience pain relief from alfentanil opposed to volunteers and patients with a low variability in pain scores.
The main hyothesis of the experiments is that a dual action antidepressant (duloxetine) modulates functions in specific brain areas involved in the processing bias of emotional stimuli in the context of neutral versus depressed mood.