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Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…
Hepatic insulin sensitivity increase after dopamine depletion, with a-methylparatyrosine (AMPT).
The effect on APC-resistance of the skin patch and the vaginal ring contraceptives, containing third generation gestagens, is significantly increased in comparison with oral contraceptives, containing second generation gestagens.
Early detection of problems and adequate coaching of frail elderly people is crucial to prevent unnecessary loss of function, decrease in quality of life, and even death in old age. This is especially true for frail elderly people who are admitted…
The flavonoid-drug interaction could potentially lead to higher nintedanib absorption by the gastro-intestinal tract. This would cause higher systemic bioavailability and lower local gastro-intestinal drug concentrations. Furthermore, inter-patient…
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…
I. Test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in remitted MDD patients and HC: Pre-and peri-intervention changes will be examined using within-subject and between-group…
The optimal management of locoregionally advanced NSCLC is evolving. Multimodality treatment is rapidly becoming the most common approach to stage III NSCLC. ASCO guidelines recommend initial chemotherapy (platinum-based, 2 or 3 cycles) combined…
Hypothesis 1: the Groningen ULR and the Provox®2 are the same in terms of the replacement method, the burden on the patient and the convenience of the replacement and of the resistance during phonation. Hypothesis 2: the Groningen ULR has a longer…
Preoperative planning with x-ray-based PSI have comparable outcome as 3D used MRI-based PSI resulting in indirectly reduced costs on storage of implants and instruments.
Autofluorescence endoscopy (AFE) has a higher sensitivity for the detection of colorectal adenomas in comparison with white light video endoscopy (WLE).
Phenylalanine supplementation can result in higher phenylalanine concentrations without causes tyrosine concentrations to rise too much
Preceding dwell with icodextrin does not influence the results of the 3.86% glucose PET in CAPD.
Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle.…
Inhalation of once daily double dose of inhaled tobramycin targeted to the small airways by the Akita (1x 300 mg instead of 2x 150 mg) is more effective in reducing small airways obstruction compared with standard of treatment: twice daily…