27 resultaten
1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…
To assess the impact of the physical form of five different cocoa matrices on the bioavailability of the monomeric flavan-3-ols.
In this randomized crossover pharmacokinetic study we will investigate the effects of cytochrome P450 enzyme induction (including CYP3A4, CYP2C and CYP2D6) by rifampicin on the metabolism and plasma pharmacokinetics of tamoxifen and its metabolites…
Primary Objective: In this trial we will investigate the efficacy of BVR using best responder criteria in patients with severe heterogeneous emphysema compared to usual care. Secondary Objective: Economic evaluation: Estimation of costs of BVR…
Compared to treatment as usual implementing Integrated Double Diagnosis Treatment (IDDT) in mental health care teams for severe mental illness (SMI) outpatient will improve a. outcomes at psychiatric symptoms and drug or alcohol abuse, and b. will…
Circadian misalignment may result in disturbed energy balance, as a consequence of decreased energy expenditure.
Effects of acupuncture (add on) treatment are investigated.
Prucalopride accelerates gastric emptying and increases esophageal contraction amplitude and LES pressure and subsequently reduces gastroesophageal reflux.
The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.
Rationale: Antibiotic resistance is a growing problem worldwide with considerable costs. It is mainly driven by inappropriate use. It is necessary to look for measures that improve prescribing in antibiotics and that stimulate both health…
It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Oral exposure time and energy content of the gastric load both effect subjective feelings of satiety, gastric emptying rate and subsequent food intake. A longer oral exposure time and a high gastric energy content would both increase subjective…
We hypothesise that there is a central mechanism that shuts down energy consumption by brown adipose tissue (BAT) during hypoglycaemia. This could be a mechanism to protect the brain from neuroglycopenia.
Are there effects of ARA290 and Epo on the ventilatory response to hypoxia. Are there effects of ARA290 and Epo on the gradient over the tricuspid valve during hypoxia a an estimation of the pulmonary artery pressure (PAPA). Does ARA290 and/or Epo…
Prevention of progressive renal function loss remains the main challenge in clinical nephrology. Blockade of the rennin-angiontensin-aldosterone system (RAAS), which can be potentiated by a low sodium diet, is the therapy of choice, but still many…
In this study we investigate the effect of ketamine on the brain. We hypothesize that ketamine influences brain areas involved in pain, cognitive function and psychosis. The study aims are: 1. To investigate the effects of 2 plasma levels of S(+)-…
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The primary hypothesis is that tube feeds with different protein sources will have different gastric emptying rates.
Gastric feeding, in an intact GI tract, will initiate a more physiological response than jejunal feeding.
Evaluation of eculizumab treatment in PNH patients at home compared to treatment at the center of excellence in the Netherlands.