27 resultaten
To assess the impact of the physical form of five different cocoa matrices on the bioavailability of the monomeric flavan-3-ols.
The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.
It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Oral exposure time and energy content of the gastric load both effect subjective feelings of satiety, gastric emptying rate and subsequent food intake. A longer oral exposure time and a high gastric energy content would both increase subjective…
Gastric feeding, in an intact GI tract, will initiate a more physiological response than jejunal feeding.
Evaluation of eculizumab treatment in PNH patients at home compared to treatment at the center of excellence in the Netherlands.
Previous studies proved that chronic low back pain (CLBP) patients’ motor performance is deviated compared to healthy subjects. This applies for performance of low back motor task, but also tasks that do not involve the back. In addition, the…
The primary hypothesis is that tube feeds with different protein sources will have different gastric emptying rates.
Red pepper might prevent reduction of energy expenditure and elevation of hunger as a result of energy intake restriction.
It is predicted that pretreatment with memantine can prevent the memory impairment that is usualy caused by MDMA.
The aim of this first study is to evaluate the use of the IFS for quantitative assessment of mobility performance in comparison with gait velocity and questionnaires already validated and studied in patients before and after THA in an outpatient…
If the intervention with mate tea and cocoa in individuals with HIV on HAART can improve the cardiovascular risk profile to prevent or reduce high blood concentrations of inflammatory markers, lipoproteins (LDL, VLDL) and triglyceride levels, reduce…
Treating children with TSC and intractable epilepsy with rapamycin in addition to their standard drug regimen will decrease the frequency of their epileptic seizures.
In this study we investigate the effect of ketamine on the brain. We hypothesize that ketamine influences brain areas involved in pain, cognitive function and psychosis. The study aims are: 1. To investigate the effects of 2 plasma levels of S(+)-…
N/A
Rationale: Antibiotic resistance is a growing problem worldwide with considerable costs. It is mainly driven by inappropriate use. It is necessary to look for measures that improve prescribing in antibiotics and that stimulate both health…
1. Patients, who still suffer from erectile dysfunction, 12 months after a radical prostatectomy, can improve their erectile function by performing an intensive therapy program for their pelvic floor muscles; 2. Patients after robot surgery have a…
Prucalopride accelerates gastric emptying and increases esophageal contraction amplitude and LES pressure and subsequently reduces gastroesophageal reflux.
In this randomized crossover pharmacokinetic study we will investigate the effects of cytochrome P450 enzyme induction (including CYP3A4, CYP2C and CYP2D6) by rifampicin on the metabolism and plasma pharmacokinetics of tamoxifen and its metabolites…
Primary Objective: In this trial we will investigate the efficacy of BVR using best responder criteria in patients with severe heterogeneous emphysema compared to usual care. Secondary Objective: Economic evaluation: Estimation of costs of BVR…