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1. During cold exposure, we aim to stimulate (lipid) metabolism of BAT and muscle tissue. During this cooling process we will perform a two meal test to study the effect of cold exposure on triglyceride metabolism. 2. We expect that after cold…
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
We hypothesize that steering DBS will lead to a greater reduction of PD motor symptoms than ring-mode DBS. We will also separately measure the effect of the two types of DBS in people who have good response to ring-mode and those who don’t.
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…
It is hypothesized that the outcome of the primary outcome parameter will be different for the test product compared to the control product.
Preterm infants often require supplemental oxygen to prevent hypoxemia and hyperoxemia. Conditions that have been associated with organ damage and an increased mortality. Newly developed techniques incorporated in the ventilator provide the…
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We expect the number of seizures to decrease with the introduction of a seizure dog. Besides the effect of seizure dogs on seizure frequency, we expect an impact on participation, well-being, health-related quality of life, healthcare resource use (…
Metformin and hydrochlorothiazide attenuate polyuria in patients treated with tolvaptan
We expect that younger children have a higher learning capacity at the end-effector level, thus they should be faster in learning to handle the visuomotor transformation task than older children.
Doxepin hydrochloride 5% cream significantly reduces pruritus in burn patients in comparison with a placebo cream
Patients with ALS are routinely prescribed riluzole, the only registered drug for the treatment of ALS. This study will evaluate the concentration-effect relationship of riluzole (100 mg) and retigabine (300 mg) on axonal excitability measures. In…
If COMET increases the saliency of positive autobiographical memories, then memories that are activated during COMET (relative to no intervention control) should show an increase over time on all primary outcome measures, irrespective of medication…
We hypothesise that in the Subacromial Pain Syndrome (SAPS), a differentiation between primary peripheral (i.e. (peri)articular) and secondary pain due to altered processing of pain, i.e. central pain sensitisation, is needed. We further hypothesise…
We hypothesize that dietary nitrate supplementation improves muscle strength and muscle endurance performance.
SPT is as effective as MRA in sleep-position dependent OSA
The primary objective of this study is to investigate if a specifically designed VR-game is able to activate the pathophysiological substrate associated with OCD in OCD patients, as opposed to healthy controls. This will be investigated by…
To determine the influence of curcumin and piperine on tamoxifen pharmacokinetics.