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Oral PHA-022121 for the acute treatment and prophylaxis Of angioedema attacks in Patients with Acquired C1-Inhibitor Deficiency

We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.

A randomized, double-blind crossover trial to investigate the effects of oliceridine and morphine on ventilatory drive and pain relief in healthy older subjects - a population pharmacokinetic/pharmacodynamic modeling study

It is expected that oliceridine has a better profile concerning dose-related analgesia and dose-related side effects, compared to morphine.

Lifestyle coaching in myeloproliferative illnesses

Lifestyle coaching will lead to reduced fatigue and improved quality of life

Ambroxol in Gaucher disease 3: n-of-1 series

Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.