69 resultaten
The main objective is to determine the change in CS parameters upon administration of tapentadol in comparison to pregabalin in patients suffering from chronic pain that has a visceral or deep somatic origin.
We want to examine the effects of both the adjustable rocker profile and the self-adjusting insole on in-shoe pressure in this patient group. We expect to find similar reductions in pressure as previously found in healthy subjects. Also, the…
We want to determine the influence and safety of probenecid on sorafenib pharmacokinetics. By inhibiting the OAT6 transporter there might be a faborable effect on Hand-foot syndrome
A new health system is being validated on heart rate variability; galvanic skin response and oxygen saturation.
The hypothesis is that the Manometric brace is superior to conventional plaster braces in terms of patient satisfaction, compliance and patient preference. For pain and hand function, no superior outcomes are expected for the Manometric brace…
The treatment with ciNPT results in a superior healing when compared to the standard treatment (no ciNPT). The rationale behind the secondary outcome is that this treatment leads to improvement of scar quality in comparison to the standard treatment…
The study hypothesis is that FFCiH will maintain or improve functional status and physical activity in hospitalized stroke and geriatric patients compared to usual care.
Inhaled levodopa provides more rapid symptom relief than orally administered levodopa
Phenylalanine supplementation can result in higher phenylalanine concentrations without causes tyrosine concentrations to rise too much
By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…
Addition of Partner for Change Outcome Management System (PCOMS) to individual treatment will result in a significant decrease of drop-out compared to individual treatment without PCOMS in a forensic outpatient clinic in the Netherlands. A sub-…
washing-without-water is 1) equally or more emotionally and physically comfortable for persons being bathed in bed; and 2) equally or less physically demanding for persons providing the bed bath.
MRI-ultrasound fusion biopsies of the prostate will detect more clinically relevant tumours (I.e. higher Gleason score) when compared to random ultrasound-guided biopsies in the primary prostate biopsy setting.
To determine the influence of the PPI esomeprazole on the absorption of capecitabine and the impact of the PPI in combination with the acid beverage Coca-Cola on the absorption of capecitabine because PPIs may profoundly decrease solubility and…
LRRK2 kinase inhibitors represent a new class of therapeutics with potential to address the underlying biology of Parkinson’s disease. LRRK2 activity is linked to a central mechanisms of Parkinson’s disease pathology through its role in lysosomal…
Standing leads to better performance on cognitive tasks regarding executive functioning.
The use of automated closed loop oxygen control in infants on infants with high flow nasal canulla (HFNC) support, will lead to higher amount of saturations within target range compared to manual control.
The hypothesis is that patients with thiopurine therapy will not be at risk of impaired semen quality.
Ankle bracing has shown to be effective for the prevention of ankle injuries in athletes. However, the working mechanism of this preventive effect remains unclear. A contributing preventive factor of ankle braces mentioned in literature is enhanced…