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We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Reduced dermal blood flow response to capsaicin application and saline iontophoresis after propranolol ocompared to placebo administration.
High-intensity stress reduces cognitive performance (visuo-spatial learning) both for immediate and delayed recall.
In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…
Objective: The overall aim of this project is to asses the prognostic value of the characteristics of an echocardiographic surrogate pressure-volume loop on mortality and morbidity due to PAH.
Pelvic floor muscle spasms resulting in chronic pelvic pain may occur as a primary event or secondary to a physical, psychological or pathological factor. First-line treatment consists of pelvic floor physiotherapy. When first-line treatment fails,…
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP
It is expected that acute challenges with cocaine will induce two opposing effect on creativity. That is, cocaine will increase mood leading to enhancement in divergent but not in convergent thinking.
Sleep (quality and quantity) is beter in ICU patients when they are nursed in a single room compared to nursing in a 'open' ICU.
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.
Use of any mask (surgical or N95) in a standard day of work for hospital staff, may result in subjective feelings of dyspnoea. These symptoms of dyspnoea do not correlate to a decreased oxygen saturation, but do correlate to baseline participant…
The percentage of curatively treatable metastatic disease after surgery for primary colorectal cancer can be increased by means of optimizing follow-up of colorectal carcinoma. Intensifying the follow-up by increasing frequency of CEA measurements…
The nephrotoxicity caused by cisplatin is of great concern both in that it is dose-limiting and can be detrimental to the patient. Much work has been done to reduce or prevent this damage to renal cells, however to date the best approach has reduced…
Budesonide does not alter the exposure of cabazitaxel in castrate resistant prostate cancer patients.
Rivastigmine can reverse a memory impairment that is induced by biperiden, which will be seen both behaviorally and in the EEG.
Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and intrapatient differences, which may have serious consequences for the activity and toxicity profile of this drug. The use of…