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The effects of vancomycin on gut bacteria and coagulation values in the blood.

Recently, (changes in) the gut microbiome (flora / bacteria) have been associated with obesity and insulin resistance, and other cardiovascular risk factors or atherogenic processes. Venous thrombosis shares these risk factors, probably by a shared…

Calcineurin-inhibitor Nephrotoxicity and Efficacy Study.

We believe that a routine graft biopsy at 6 and 12 months together with graft function represents the best surrogate marker for late graft loss.

Modifications in implant features in the TFNA proximal femoral nail as successor of a more conventional intramedullary nail were associated with an increase in fixation failure rate.

No improvement of fixation failure will be found after the introduction of the TFNA

A study for all children and adolescents with a low grade glioma.

The goal of this study is: 1. To offer a uniform, standardized concept for the treatment of children and adolescents affected by low grade glioma; 2. To improve progression free survival following non-surgical therapy for children without NFI with…

Demineralized bone matrix (DBM) as an alternative for autogenous bone graft in high tibial valgus opening wedge osteotomy (HTO) for symptomatic medial compartmental knee osteoarthritis.

Opening wedge HTO treated with DBM will better match one year post-operative mechanical axis alignement with pre-operative planned correction then opening wedeg HTO filled with autogenous iliac crest bone.

Improving the efficiency and quality of follow-up after curative treatment for breast cancer.

1. Regular physical follow-up can partly be replaced by nurse-led telephone follow-up, with at least similar quality of life (QoL), in breast cancer patients treated with curative intent. ( change in QoL < 5 points) 2. An informative/…

Treatment of Fabry patients > 18 years with enzyme supplementation therapy: comparison of efficacy and toxicity of low dose (0,2 mg/kg) fabrazyme (agalsidase beta) or replagal (agalsidase alfa).

Evaluation of efficacy and safety of two different formulas of alfa-Galactosidase A, agalsidase beta (FabrazymeTM) and agalsidase alpha (ReplagalTM) in an equal dose of 0,2 mg/kg in order to detect any differences between these two drugs.

Screening and treatment of malnourished hospital patients.

1. The recognition of malnourished inpatients will improve by using the SNAQ malnutrition screening tool at admission; 2. Early recognition and treatment of malnutrition is effective and cost effective.

Effects of STB™ wounddressing on nasal woundhealing after radiofrequency coblation treatment of the inferior turbinates

treatment with STB wound dressing in combination with nasal saline irrigation, after coblation of the inferior turbinates, provides better wound healing compared to nasal saline irrigations only.

Phase 3 trial of the antiangiogenic agent thalidomide in patients with malignant mesothelioma after first line chemotherapy.

Maintenance thalidomide delays the time to progression with 50% in patients who do not progress after > 3 cycles of pemetrexed containing chemotherapy.

Optimale dosering voor een ruggenprik bij kortdurende operaties.

We will establish the optimal dose chloroprocaine for knee-arthroscopy

A randomised controlled trial for the effect of preoperative physiotherapy in patients with an increased risk for the development of postoperative pulmonary complications after open-heart surgery.

Preoperative physiotherapy decreased the incidence of postoperative pulmonary complications (PPCs) after open heart surgery on patients with an increased risk of developing PPCs.

Hot water immersion as a strategy to promote post-exercise recovery in healthy young men.

We hypothesize that post-exercise HWI increases muscle protein synthesis rates.