389 resultaten
Cabazitaxel is a tubulin-binding taxane drug that improves survival of patients with docetaxel-metastatic-castration-resistant prostate cancer (mCRPC). Unfortunately, cabazitaxel is not effective in all patients and can have serious side effects.…
The aim is to examine the natural course of Acute Stress Disorder (ASD) symptoms (aim 1) and the effects of these symptoms on the development of Port-Traumatic Stress Disorder (PTSD) and patients¡¯ psychological distress (i.e., anxiety and…
A decline of intra-tumoral concentrations over time could be the first sign of the development of drug resistance by the tumor. In this exploratory study we will investigate the relationship between plasma and intra-tumoral paclitaxel concentrations…
An early mobilization program in critically ill children reduce the consumption of sedatives and opioids and the prevalence of delirium.
Most studies that aimed to discover new IBD biomarkers on a protein level have mainly focused on plasma/serum. However, recent studies suggest that analysing material closer to or directly from the location of disease may yield higher concentrations…
Remote patient reported outcome measures (replacing partial Mayo) can be used for monitoring continuous clinical control of UC disease
We expect that the older patients with SMI have more somatic health problems, disorders and complaints, compared to the adult patients with SMI.
Combining factors will enable prediction of successful long-term video-EEG monitoring and of adverse effects, related to antiepileptic drug withdrawal.
Repetitive ePIPAC-OX as a palliative monotherapy is a feasible, safe, tolerable, and potentially effective treatment for isolated unresectable colorectal peritioneal metastases, with low and predictable costs and a low systemic uptake of oxaliplatin…
Providing vascular surgical patients and vascular surgeons with decision support tools will improve the level of shared decision-making during consultation, increase disease-specific knowledge and quality of life and decrease decisional conflict.
In pregnancies complicated by late PPROM immediate delivery might lead to better long-term outcome.
to assess the detection rate and accuracy of 18 F-FDHT PET/CT and compare to current standard restaging modalities.
The study will address the feasibility of the shared decision-making (SDM) intervention by (1) analysing the acceptability of the intervention by users (i.e. professionals and patients); (2) assessing the level of implementation; (3) testing…
1. We first propose that in advanced TC, not only tumor-associated macrophages (TAMs), but also circulating monocytes and bone marrow (BM) myeloid progenitors are functionally reprogrammed by tumor-derived metabolites even before their recruitment…
Patients undergoing superior capsule reconstructions (SCR) for superior shoulder instability will experience less pain (decrease of at least 2 points) and improved function.
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
DBS-related cognitive decline and psychiatric side-effects in Parkinson's disease (PD) patients can be studied from a functional- and structural network point of view. We will characterize functional and structural brain networks in PD patients…
1) Epidemiology of postoperative pain What is the correlation between pain intensity scores and type of surgical procedure in relation to patient characteristics and analgesia? Is it possible to specify surgical procedures indicating its pain…