126 resultaten
Nadroparine and fondaparinux are both effective in preventing a thromboembolic event in patients with a nonsurgical fracture of a lower extremity immobilised in a below-knee plaster cast.
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using intermitted thermodilution cardiac output in critical ill patients.
The following research questions will be determined: 1. What is the effect of an nutritional intervention compared to usual care in undernourished patients of 65 years in general practice or using home care? 2. What is the cost effectiveness of an…
This is a dose-escalation study to determine the safe dose of clofarabine given in combination with cytarabine and liposomal daunorubicin.
The aim of this study is to assess barriers and facilitators of implementation of external cephalic version in The Netherlands, and to develop an innovative implementation strategy based on improved patient counselling and information of health care…
Sleep (quality and quantity) is beter in ICU patients when they are nursed in a single room compared to nursing in a 'open' ICU.
To quantify the amount of local anaesthetic in blood and tissue fluid in the Bellovac ABT system and in the blood circulation of the patient. The primary objective is to quantify the cumulative ropivacaine level when the blood should be retransfused…
We hypoothesize that the effect that a single dose of montelukast has on exercise induced bronchoconstriction correlates with the effect it has after 8 weeks of treatment.
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
Presence of postural instability and gait dissorder PIGD (gait disorders, balance impairment, falls, fal-related injuries and FOG) are an important and disabling feature of idiopathic Parkinson’s disease (PD) where the level of functional ability is…
Multiple Endocrine Neoplasia type 1 (MEN1) and Von Hippel-Lindau disease (VHL) are rare autosomal dominantly inherited disorders characterized by the occurrence of various tumors. Therefore, mutation carriers undergo regular screening (yearly for…
The incidence of gastric cancer has been declining steadily since the 1930s, but it remains a major cause of cancer death in the Western world. The high mortality rate reflects the prevalence of advanced disease at presentation. The five-year…
Pregnancy rates will not differ between patients with a positive and negative result of the PCT.
To assess the current indications for URS and the treatment outcomes in terms of the stone free rate.
The purpose of the study is to conduct a randomised controlled trial with the training course 'Less stress through mindfulness' as an intervention to study the: 1. Effectiveness in terms of reduction of psychological symptoms (depressive…
DYANA Study - Dynamic Annuloplasty System with Activation for the Treatment of Mitral Regurgitation.
To assess the safety and efficacy of the MiCardia Dynamic Annuloplasty System for the treatment of mitral regurgitation with optional intraoperative activation and optimization.
A slow and unpredictable deterioration of the capabilities of the older patient can lead to a vulnerable situation, often unnoticed by the caregiver. As a consequence, care is delayed and acute problems will arise that will need an immediate…
PHASE 1: 1. Identify the extent to which care management (as a competency) is implemented in the curriculum of postgraduate medical education in the Netherlands; 2. Evaluate stakeholders’ perceptions of the concept of care management (in medical…