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The primary objective of the study is to determine: • Adherence for second round CRC screening with one-sample iFOBT (OC-Hemodia Latex) comparing annual, biennial, and triennial screening interval. • Adherence and diagnostic yield of a first…
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The aim of the present study is to determine the impact of national PCV-7 implementation on NP pneumococcal carriage in children of 11 and 24 months of age and to evaluate NP colonization of one parent of a 24-month-old child.
Phase II part: - Null hypothesis (H0): (s)CR+VGPR rate = 15% - Alternative hypothesis (H1): (s)CR+VGPR rate = 30%
Muscle weakness in patients admitted to the Intensive Care Unit lengthens duration of mechanical ventilation, weaning and hospital stay. One of the causes for muscle weakness is critical illness polyneuromyopathy (CIPM). The incidence of CIPM varies…
The prodrug tamoxifen is metabolized to its most potent metabolite endoxifen by the enzyme CYP2D6. Up to 25% of Caucasians harbour genetic variants leading to a less active CYP2D6. This may lead to lower endoxifen levels and thus lower tamoxifen…
We will study which factors differ between the responders to oxygen therapy and the non-responders. Factors that will be studied are for instance patient characteristics, headache characterisics, comorbidities and intoxications.
The goal of this study is to answer the following questions: 1. Is initiation of mechanical ventilation at home equally effective in improving gas exchange as compared to the initiation of it in the hospital? 2. Is initiation of mechanical…
Patients with a combination of COPD and CHF who receive a small-group community based reactivation programme will have a higher exercise capacity and quality of life after completing the programme compared to before.
The ICSI procedure interferes with the process of X chromosome inactivation in human embryos
Combination of biatrial pacing and class III anti-arhythmic drug Sotalol will significantly reduce incidence, frequency and duration of postoperative atrial fibrillation.
Aspirin (acetylsalicylic acid) is the cornerstone of primary and secondary cardiovascular disease prevention, but its preventive effects are reduced in the presence of diabetes mellitus. Whether hyperglycaemia plays an important role in the reduced…
Long-chain triglyceride (LCT) emulsions with very small droplet sizes (fine emulsion) will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with relatively large droplet sizes (coarse…