168 resultaten
To determine the MTD of pazopanib in combination with docetaxel dosed according to two regimens (3-weekly infusion[Arm A]; weekly infusion [Arm B]), in subjects with solid malignancies.
A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CTPET has a high accuracy to predict pathologic complete response after chemoradiotherapy in locally advanced rectal cancer.
The expectation is that fear of childbirth and additional pain are important reasons for choosing analgesia, or at least influence the choice. An expected reason for not choosing analgesia is that it could be detrimental for the (unborn) child. It…
Electrical stimulation on the foot and lower leg will increase the blood flow and thereby the amount of oxygen to the skin. Our overall hypothesis is that this will help to reduce the risk of decubitus on the heel. The specific hypothesis for this…
The culturally adapted version of the web-based guided self-help intervention Alles Onder Controle(in Dutch and Turkish) will reduce symptoms of depression among Turkish adults living in the Netherlands.
Fluorescent near-infrared imaging can accurately detect pancreatic cancer non-invasively during a whipple procedure.
Skin temperature can possibly affect the effect of scalp cooling. First a pilot study will be conducted to check the feasibility of the main study. The primary objective of the main study is to identify a cut-off score under which alopecia can be…
There have been several studies that showed a possible positive effect of electrical stimulation on wound healing. One of the working principles is increasing blood flow. This could mean that by giving frequent electrical stimulation on the foot and…
The objective is to assess which Transfusion Triggers are used in Blood-conserving Trials in Lower Limb Arthroplasty and to assess the prevalence of usage of Transfusion Triggers in time.
Flumazenil is a substrate of P-glycoprotein at the blood-brain barrier.
Our hypothesis is, that the extrinsic mechanism in the etiology of SIS is only valid for a subgroup of patients; complaints of SIS can be caused by 1) a pathologic pattern of arm-scapula movements caused by a disrupted balance in muscle forces,…
1. To determine the reproducibility and sensitivity of the Energy Cost of Walking test (ECWT) in boys with Duchenne muscular dystrophy, in comparison with the reproducibility and sensitivity of the 6-Minute Walk Test (6MWT); 2. To evaluate the 1-…
By sufficient electrical stimulation of the ampullary nerves, a congruent vestibulo-ocular reflex will occur.
(Short) stay and, if possible, treatment at the PMU, will give an improvement in regular psychometrics or at least in some of them.
Previous randomised trials have shown the efficacy of etanercept in RA patients. In this study we will evaluate the respons of etanercept in anti-TNF naive patients compared to patients who have failed other anti-TNF. We will look for clinical…
Patients with a wrist trauma represent a substantial part of the patient population at the Emergency Department. Most hospitals routinely carry out a radiological examination of patients following wrist trauma to exclude a distal radius/ulna…
Missing doses and early discontinuation are two levels of inadequate drug adherence. Multidisciplinary interventions may improve adherence. We hypothesize that in patients with multiple sclerosis (MS) certain modalities or durations of care are…
Current methods of detecting the presence and/or prognosis of prostate cancer are not optimal. New markers will provide better detection and/or better methods to determine prognosis. In addition, there are currently no methods available to properly…
Video images are superior to photographs in conclusively documenting the 'critical view of safety' during laparoscopic cholecystectomy.
The goal is to achieve a more sensitive method for detecting malformations of cortical development. The main hypothesis in the current study is that focal cortical dysplasias have abnormal connections. Therefore we aim to characterize the functional…