168 resultaten
Combination therapy consisting of cytotoxic drugs and multitargeted therapy is needed to improve the dismal prognosis of the multiresistant malignant pontine gliomas.
In this study we will evalute the potention of HistoScanning guided biopsy to increase the detection rate of prostate cancer.
For BE patients with visible lesions containing high-grade dysplasia (HGD) or early cancer (EC) upon biopsy, a single session treatment in which the BE is first ablated using radiofrequency ablation (RFA) followed by the endoscopic resection (ER) of…
Prolactinomas influence angiogenesis.
There is incomplete adherence to the recommendations from the guidelines on caesarean section among Dutch gynaecologists.
We postulate that exhaled breath sampling by an electronic nose can adequately identify asthma or COPD in breathprints from patients with an intention to diagnose.
The protein status of an individual effects food preferences and intake. If the protein status is high, choice and intake of high-protein foods will be decreased. If the protein status is low, choice and intake of high-protein foods will be…
Therapeutic hypothermia is the standard of care in perinatal asphyxia. Current medication protocols for hypothermic neonatal patients are largely based on personal experience or experience in normothermic patients. Evidence based dosing schedules do…
Since previous studies suggest that an influenza vaccination is probably less or even not effective in rituximab treated RA patients, we want to investigate if this also holds true for this new vaccine against the H1N1 virus.
By validating translabial 3D ultrasonography we will have a new method for selecting patients at risk for recurrence after primary conventional pelvic organ prolapse surgery by diagnosing levator defects in the pelvic floor.
Based on our large retrospective analysis, we expect an increase in the number of patients above 50 years in whom pulmonary embolism can be safely ruled on the basis of the new age-adjusted D-Dimer cut-off, but without additional imaging. Especially…
A decreased adipose tissue blood flow results in adipose tissue hypoxia, which in turn may contribute to the development of insulin resistance.
Medication review in patients at risk for hospital admissions related to medication may prevent these admissions.
A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CT-PET and biological characteristics obtained from tissue or blood has a high accuracy to predict overall survival and local control…
In this phase II study the main objective is the assessment of the occurrence of anastomotic leakage with the use of the C-seal. The assessment will take place one week after the operation, and 6 and 12 weeks after the procedure.
Primary objective: 1. To assess the prognostic value of MM related bone disease as detected by FDG-PET in terms of progression free survival; 2. To determine the conversion rate, defined as complete normalization, of FDG-PET-CT, after 3 cycles and…
The objective of the present study is to investigate the endogenous insulin response in critically ill children with hyperglycemia in relation with clinical factors and hormonal, metabolic and immunologic parameters.
All polyethylene tibial components in total knee arthroplasty in rheumatoid arthritis patients gives durable long term results.
The goal is to achieve a more sensitive method for detecting malformations of cortical development. The main hypothesis in the current study is that focal cortical dysplasias have abnormal connections. Therefore we aim to characterize the functional…