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The primary objective of this explorative study is to evaluate the training effect on the upper extremity function in children with Cerebral Palsy using the Wii computer, which is a Virtual Reality intervention. The secondary objective is to…
We hypothesize that the molecular and systemic response to calorie restriction is more explicit in obese compared to normal weight individuals to explain there propensity to grow obese.
Patients suffering from high risk or relapsed leukaemia or high risk MDS can only occasionally be cured with conventional chemotherapy. Allogeneic stem cell transplantation (allo-SCT) has substantially improved the outcome of such patients due to a…
Since previous studies suggest that an influenza vaccination is probably less or even not effective in rituximab treated RA patients, we want to investigate if this also holds true for this new vaccine against the H1N1 virus.
In this phase II study the main objective is the assessment of the occurrence of anastomotic leakage with the use of the C-seal. The assessment will take place one week after the operation, and 6 and 12 weeks after the procedure.
Cardio-vascular disease is increased in RA. Everolimus has shown to have beneficial effects on endothelial function in cardiac tranplant patients and renal transplant patients. We want to study the effect of everolimus in patients with active RA.
A decreased adipose tissue blood flow results in adipose tissue hypoxia, which in turn may contribute to the development of insulin resistance.
To assess the current indications for HPS greenlight laser treatment and the treatment outcomes in terms of objective and subjective improvement.
The aim of the meta-analysis is to further investigate the early predictive value of migration measured by RSA 1 year post-operatively for revision for aseptic loosening in TKA and to compose migration thresholds for safe and efficient clinical…
Our primary objective is to compare the short-term (one-year follow-up) clinical results of the DePuy Delta Xtend reversed shoulder prosthesis with conservative treatment, in the management of displaced four-part fractures of the proximal humerus of…
To assess the nutritional status and dietary habits of children aged 0.5-12 years in Indonesia, Malaysia, Thailand and Vietnam.
This study is designed to determine safety and toxicity of the administration of autologous DC electroporated with mRNA encoding the early expressed HIV-1 proteins Tat, Rev and Nef in patients who are virologically and immunologically responding to…
The inter-individual pharmacokinetic and pharmacodynamic variability for the anticancer drugs docetaxel and paclitaxel is due to patient characteristics, genetic variability and life style factors.
Diabetes patients have an elevated risk to develop sexual dysfunctions. These sexual problems can have a negative impact on the quality of life of these patients. Despite this negative influence, little attention seems to be paid to these sexual…
People of South-Asian/Indian descent, such as the Hindostani population in The Hague, develop DM2 at a much younger age and lower BMI as compared to Caucasian controls of the same age and BMI. Moreover, the incidence and seriousness of…
The addition of panitumumab to radiotherapy plus gemcitabine will increase the number of patients who are alive and progression free at 7 months.
Mitoxantrone depletes mainly pro-inflammatory T- and B- cells. Anti-inflammatory cells are spared.
The purpose of this study is: 1. To develop a method to quantify muscular fat content in brachial plexus injury patients; 2. To investigate whether muscular fat content is more in the affected arm compared to the contra lateral arm in BPI patients;…
Replacing bortezomib by carfilzomib would associate effective proteasome inhibition with lack of neuropathy, thereby improving the proportion of patients who are able to complete the planned treatment and reducing the rate of serious adverse events…
Pilot research in experienced centers has suggested two surveillance strategies in patients with ulcerative colitis to be more efficient than standard endoscopy: (1) ETMI (endoscopic tri-modaility imaging), utilizing AFI and narrow band imaging (NBI…