171 resultaten
The UKPDS study showed that good glycemic control in patients with type 2 diabetes mellitus (DMT2) results in a significant reduction in microvascular complications. A long-term follow-up extension of the study revealed that early intervention and…
The control of voluntary movement involves different parts of the central nervous system. The involvement of the cortex in the control of movement is not always incorporated in research on motor control. In this study we will use system…
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are relatively rare liver diseases that in most cases lead to liver failure in 10-20 year. Nowadays, both diseases are regarded as immune dysbalance disease entities, but in…
Selection of the best embryo for transfer is the key to achieve high implantation rates and is still largely based on morphological assessments at fixed time points. Newly emerging techniques, enabling safe time-lapse photography of embryo…
The hypothesis is that 15% more patients in the comprehensive care pathway compared with patients in the care as usual condition will recover at least as well at 6 months follow-up as before the fracture in Activities of Daily Living.
The exercise therapy program ‘Fitkids’ is effective to increase physical fitness, muscle strength and health-related quality of life in children with chronic conditions or disabilities.
Does addition of lenalidomide to chlorambucil and rituximab result in better response rates with acceptable toxicity.
In this randomized crossover pharmacokinetic study we will investigate the effects of cytochrome P450 enzyme induction (including CYP3A4, CYP2C and CYP2D6) by rifampicin on the metabolism and plasma pharmacokinetics of tamoxifen and its metabolites…
Main question: What is the value of the propensity for reinvestment (measured by the Movement Specific Reinvestment Scale) in predicting the functional mobility (measured with he Rivermead Mobility Index) of stroke patients after 15 weeks of…
The aim of this study is to validate the Dutch versions of the PainDETECT questionnaire PD-Q and the ‘Douleur neuropathique en 4 questions’ (DN4) for use in primary and specialist medical care settings for patients with LBP and NSP and patients with…
The depression prevention program ("Op Volle Kracht") will be delivered by teachers in the school curriculum in schools with adolescents from high-risk background. It is expected that adolescents who receive the interventions will show…
Early recognition of deteriorating patients is key to possible effectiveness of an RRS. Therefore, phased introduction of the afferent limb (aimed at detection) followed up by the implementation of the efferent limb (the Medical Emergency Team) will…
The (long term) effectiveness of a school-based universal depression prevention program (“Op Volle Kracht”) will be tested in a Dutch sample of adolescents (aged 12-14 years). It is expected that adolescents who receive the intervention will show…
Effects of acupuncture (add on) treatment are investigated.
A high dose of rosuvastatin significantly decreases or halt the progress of the necrotic core volume present in a non-intervened coronary segment as assessed by IVUS-VH.
We hypothesize that CTX patients, when untreated for a short period, differ from matched healthy controls in the response to a test meal. CTX patients are expected to have lower postprandial GLP‐1 and insulin levels with higher plasma glucose and…
For patients with breast cancer who are not applicable for breast-saving treatment (because of tumor characteristics), who prefer an amputation or who undergo a prophylactic amputation an immediate breast reconstruction is a standard offer. A…
Good oocyte quality and maturity are important prerequisites for higher fertilization and implantation rates in IVF/ICSI treatment cycles. Reactive oxygen species (ROS) are produced within ovarian follicles, especially during ovulation process, and…
EN - Unrelieved chronic pain represents a major problem for individual patients and is also a socio-economic burden for health services and the community at large. Although the etiology of musculoskeletal chronic pain following trauma is not well…
We hypothesize that a combined intracoronary pressure-flow measurement directly after percutaneous coronary intervention is a measure for predicting the occurrence of microvascular obstruction in the days following the acute event.