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We postulate that exhaled molecular profiling obtained from ‘breathprints’ by electronic nose: 1. Is associated with the level of asthma control and; 2. Is associated with an inflammatory profile in induced sputum and blood in steroiddependent…
Part A: In clinical practice the use of simplified quantitative methods and procedures can be fully validated against complex quantitative kinetic measures. Part B: Test-retest repetability of different SUV measures, metabolic and anatomic volume…
Our first hypothesis is that in the two exisiting case management models, the persons with dementia will have less behaviour and mood problems than persons receiving usual care and informal caregivers experience better mental health compared to…
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Electrical stimulation of the sympathetic pathways by cervical spinal cord stimulation increases cerebral blood flow.
The robotic-assisted technique will allow the ascertainment of ‘Critical View of Safety’ in all anatomical variations.
Uterine cervical cancer is the second most common female malignancy. Therapy monitoring is essential to detect early recurrence. Diffusion-weighted magnetic resonance imaging is an emerging MRI imaging technique which has a potential value for the…
We expect that irrational thoughts and maladaptive coping strategies will be positively changed. As a consequence of this intervention, there should be a significant decrease of: 1. The amount of cyber bullying victims; 2. The psychosocial problems…
Near-infrared fluorescent imaging can accurately detect neuroendocrine tumors non-invasively during surgical procedures.
B cells play a role in multiple sclerosis, not only by production of autoantibodies but also by presentation of (auto)antigens to autoreactive T cells.
The hypothesis is that all patients with rising RT-qPCR MRD levels of specific genetic markers in pediatric AML patients in CR1 invariably will develop overt clinical relapse.
To quantify health risks in relation to preventive actions and consequences of illness related to travel in immigrant and non-immigrant immunocompromised travellers treated with MTX and/or anti-TNF-alpha monoclonals, imuran or rituximab.
The goal of this study is to get insight into the preconditions and feasibility of participation of elderly residents with dementia en family members in nursing homes. The research questions are: Which preconditions are necessary to sucesfully…
There is underdiagnosis of COPD. To solve this problem, we want to check healthy persons after a questionnaire on high risk of COPD.
Long term quality of life of patients with iatrogenic bile duct injury due to cholecystectomy is lower than in patients with an uncomplicated cholecystectomy.
The purpose of this study is to evaluate the feasibility (safety and effectiveness) of the AEGEA GEA System to reduce menstrual blood loss in women with a history of menorrhagia due to benign causes.
The hyperfiltration hypothesis implies that children with a solitary functioning kidney are at risk to develop hypertension, (micro)albuminuria and chronic kidney disease. We aim to develop an individualized risk profile for children with a solitary…
The aim of this study is to assess the ability of PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of treatment can discriminate between pseudo progression and true progression as measured by MRI at 10 and 22 weeks,…