30 resultaten
Therapeutic drug monitoring is effective in optimizing treatment with tobramycin and reduces side effects.
Delivery of a generic MBSR training to patients who visit a memory clinic with cognitive complaints, and who show no clinical signs of a cognitive disorder, is feasible.
This study primarily aims to explore changes in physical activity pattern and energy expenditure in head and neck cancer patients, during and after treatment with surgery with or without (chemo)radiation. The following primary null hypotheses will…
Two hours of end-ischemic hypothermic oxygenated perfusion via both the hepatic artery and the portal vein is feasible and safe in resuscitating liver grafts procured from donation after circulatory death donors.
We will investigate the effects of high dairy intake on metabolic flexibility, glucose metabolism and insulin sensitivity, which are all important characteristics of (metabolic) health. We hypothesize that high dairy intake improves insulin…
The effect of pulse rate on temporal resolution and speech intelligibility in cochlear implant users
CI pulse rate is known to affect temporal resolution and speech intelligibility. Based on literature it is hypothesized that low pulse rates decrease temporal resolution, but increase speech intelligibility.
The objective of this study is to describe a pharmacokinetic profile of total and unbound plasma concentrations ropivacaine, when used for local infiltration analgesia in total knee arthroplasty
patients with diabetic cardiovascular autonomic neuropathy are more prone to hypotension during surgery and therefore require more inotropic/vaspressor medication perioperatively
The aims of the study are: 1) To investigate the effectiveness in diminishing behavior problems of Behavioral Parent Training Groningen (BPTG) for parents of children with an ASD and behavioral problems between 4 and 13 years of age in two formats…
We hypothesize that age-related changes in hepatic and intestinal drug metabolism affect the pharmacokinetics of paracetamol.
We expect that when the developed checklist will be used in de diagnostic proces of children with developmental and/or behavioral disability, the use of pediatric care will be more efficiently used. Over and underdiagnoses of a causal somatic…
The main hypothesis is that normo-ovulatory women with a deleterious BRCA mutation have lower levels of AMH compared to normal controls, with at least a difference of 0.90 ng/ml, suggesting an effect size of approximately five years in menopausal…
- The diagnostic accuracy of ultrasound assessment regarding the synovium in patients with haemophilia is > 70%. - Soft tissue changes on initial MRI are associated with osteochondral changes on re-examination after 5 years…
We propose to evaluate the beneficial effects of adding a contingengy management (CM) intervention, aimed at a reduction of cocaine consumption, to the current heroin-assisted treatment. This intervention – combined heroin-assisted treatment plus CM…
To investigate the differences in short-chain fatty acid metabolism, markers of local (intestinal) and systemic inflammation and markers of bacterial translocation between type-1-diabetes patients and healthy controls and to relate these differences…
Vitamin C deficiency may play a role in the symptoms of patients with chronic kidney failure and eventually renal replacement therapy
Aims: 1. To determine the prevalence of subjective sleep disturbances and the influence on quality of life in people with epilepsy compared to people without epilepsy 2. To explore the factors which contribute to sleep disturbances in people with…
Objective: to investigate in vitro a relationship between plasma free haemoglobin and extracorporeal life support-related parameters such as pump flow, catheter selection, pump speed and pump heating. 1. Blood flow is positively related to plasma…
- A new sensorbased gait analysis measurement as a simple and quick diagnostic/monitoring tool to evaluate joint status and changes in gait pattern in hemophilia patients. - Possibility to detect a disturbed gait pattern in clinically asymptomatic…
Disturbances in the circadian rhythm could be a possible cause for development of delirium.